Hexamethylphosphoramide Market: Information by Type, Form (Specialty Solvent, Oxidant), and Region — Forecast till 2029

Feb 08, 2021   Hexamethylphosphoramide (HMPA) refers to a colorless organic liquid medium ammonia flavor that is found to be soluble in both polar and non-polar solvents. It is a highly efficient organic catalyst that is responsible for the reversible-deactivation radical polymerization of methyl methacrylate. It is made from the reaction of dimethylamine and phosphorus oxychloride and is used as a polymer-solvent for various applications such as a laboratory solvent for organometallic and organic reactions, s...
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Hexamethylphosphoramide (HMPA) refers to a colorless organic liquid medium ammonia flavor that is found to be soluble in both polar and non-polar solvents. It is a highly efficient organic catalyst that is responsible for the reversible-deactivation radical polymerization of methyl methacrylate. It is made from the reaction of dimethylamine and phosphorus oxychloride and is used as a polymer-solvent for various applications such as a laboratory solvent for organometallic and organic reactions, selective solvent for gases, and a stabilizer in polystyrene against thermal degradation.

Hexamethylphosphoramide helps in improving the selectivity of certain organic reactions. It can be used as an anti-corrosion agent of PVC and other kinds of chlorine, which contains resin products and coatings. It is also used as an ultraviolet inhibitor, gas chromatographic fixative, and rocket fuel additives for lowering the freezing point.

Apart from this, it is used in a variety of processes and applications, such as a solvent, chemosterilant, gas chromatographic fixative, and thermal stabilizer. It is used as a solvent to convert carboxylate salt into esters by reacting with alkyl halides. Esters are a chemical amalgamation between alkyl and a substitute for hydrogen of an acid. Some of the naturally obtained esters include oils, fats, and triglycerides, which have the least impact on the health of humans and are continuously in demand due to their high-performance and custom design versatility.

They are used in the industrial application sector and are in high demand in several niche markets. In addition to this, it is used as a chemosterilant for a number of insect pests and chemical mutagen as it causes reproductive sterility in an organism. It is used to control the economically destructive or disease-causing pests, which are done by either causing temporary or permanent sterility of one or both of the sexes. Furthermore, it is also used as a weathering solvent of polyvinyl chloride and polar solvent, which significantly affects the aging and low-temperature resistance of the agricultural films.

Growing Demand for Hexamethylphosphoramide in Solar Industry

Solar energy is the most convenient renewable solution and a highly efficient form of unconventional energy that reduces greenhouse emissions and global warming. The solar industry has been growing rapidly, owing to the increasing environmental pollution and initiatives and support from various governments across the globe to install solar panels. Apart from this, the demand for solar energy systems is witnessing a significant surge in the power generation sectors. As per Solar Power Europe, solar energy alone reached a total share of 12.1% in the global total power output in 2017.

As per the Journal of Materials Chemistry, a 17% efficient perovskite solar mini-module was created with hexamethylphosphoramide (HMPA) as the lewis base additive. Perovskite solar cells convert visible light and ultraviolet into electricity. They also have tunable bandgaps, which means they can be easily custom-designed and hexamethylphosphoramide has helped in forming a denser and uniform perovskite film with high optoelectronic quality. 

Use of Hexamethylphosphoramide in PVC

The increased use of PVC in different industries is anticipated to surge the demand for hexamethylphosphoramide during the forecast period.

PVC refers to a very durable and long-lasting material, which falls into the category of thermoplastic resins that are hard plastics but can be softened through heating. It is made of 57% chlorine and 43% carbon and uses more renewable resources for its production. PVC is the world's third-most widely produced synthetic plastic polymer that is versatile, durable, affordable, and recyclable. It is used for a broad range of applications, such as window frames, cables, sports equipment, pipes, flooring, furniture, and a range of life-saving medical devices.

Hexamethylphosphoramide acts as the light stabilizer of PVC, which enables amazing anti-aging properties of outdoor products and excellent weather resistance. Thus, the use of hexamethylphosphoramide in PVC is increasing, further increasing the demand for PVC in various industries for its various advantages. As per the European Council of Vinyl Manufacturers, around 70% of the PVC is used for durable, affordable, and recyclable building and construction products. The council also stated that in the EU-28, about 6.5 million tons of PVC products are manufactured every year, further driving the demand for hexamethylphosphoramide.

Toxic Effects of Hexamethylphosphoramide

The carcinogenic solvent of hexamethylphosphoramide hinders the market growth. The researchers are compelled to look for better options, such as DMI, due to safety reasons. As per the Journal of Chemical Ecology, 19 out of 21 carcinogens are active in HMPA, whereas 3 out of 6 non-carcinogens were active in the Drosophila system.

Hexamethylphosphoramide is known to have toxic effects on experimental animals. The repetitive application of hexamethylphosphoramide on the skin of rabbits leads to weight loss, neurological disorders, and changes in gastric functions. Additionally, it initiates acute poisoning in rats leads to severe bronchiectasis and bronchial pneumonia. The oral administration of this liquid can cause semen deficiencies and testicular atrophy.

According to various studies, it has also been seen that upon inhaling HMPA, the rats start showing nasal tumors after eight months after getting exposed to 400 to 4000 ppb HMPA. In some of the mice, cancer has also been shown to be initiated. Therefore, the use of hexamethylphosphoramide on animals may get restricted in the near future.

Regional Overview

Growing Use of Polyvinyl Chloride in Europe Drive the Hexamethylphosphoramide Market

Europe holds the largest share in the hexamethylphosphoramide market on account of the growing use of polyvinyl chloride or PVC, which uses hexamethylphosphoramide to enable amazing anti-aging properties of outdoor products with excellent weather resistance.

As per the European Council of Vinyl Manufacturers, around 771,000 tons of PVC gets recycled each year, and the annual European consumption of PVC totals 5 million tons, which is 10% of all the plastics used in Europe. In addition to this, the increasing demand for plastics in various industries boosts the demand for PVC and hexamethylphosphoramide. As per the European Plastic Converters, the plastics industry makes a considerable contribution to the welfare in Europe by creating a turnover of 308.93 USD billion annually.

The burgeoning solar sector in this region propels the market growth of hexamethylphosphoramide as these are used in converting visible light and ultraviolet into electricity. According to Solar Power Europe, the solar power generation share increased to 48% compared to 42% in 2018. The sector saw an increase in the growth by 13% to 116.9 GW, marking a new annual installation record in 2019 over 8.2 GW in 2018.

Burgeoning Renewable Energy Sector in North America to Surge the Demand for Hexamethylphosphoramide in North America

The surging renewable energy sector primarily drives North America's hexamethylphosphoramide market. Hexamethylphosphoramide is used for the manufacturing of an efficient perovskite solar mini-module to generate electricity. As per the report shared by the U.S. Energy Information Administration, Monthly Energy Review, April 2020, the consumption of renewable resources, such as biomass, solar, geothermal, and wind energy, in the U.S. was three times greater in 2019 than in 2000. This shows that the country is working towards bringing a change in the consumption of renewable resources.

As per the National Renewable Energy Laboratory, the U.S. PV market was the second-largest in terms of both cumulatively and annual installations in 2018, which signifies the rapid growth of the solar industry. Moreover, the growth of the pharmaceutical sector in this region is projected to boost the demand for hexamethylphosphoramide due to the surging use of PVC in medical devices, which are expected to grow in the coming years.

Key Players

  • BASF SE
  • Masuda Chemical Industries Co Ltd
  • Alfa Chemistry
  • CarboMer
  • Apollo Scientific Ltd
  • AccuStandard
  • Dr Ehrenstorfer GmbH
  • Ningbo Huajia Chemical Co Ltd
  • Jiangxi JixiangPharmchemical Chemical Co Ltd.
  • Jinan FuFang Chemical Co Ltd

Hexamethylphosphoramide Market: Segmentation

By Type

  • 0%–99.5%
  • >99.5%

By Form

  • Specialty Solvent
  • Oxidant

By Region

  • North America
  • Europe
  • Asia-Pacific
  • Central and South America and the Caribbean
  • The Middle East and Africa

Frequently Asked Questions (FAQs)

Growing demand for hexamethylphosphoramide in solar industry, increased use of PVC in different industries are the key factors expected to drive Hexamethylphosphoramide Market during the forecast period.
BASF SE, Masuda Chemical Industries Co Ltd, Alfa Chemistry, CarboMer, Apollo Scientific Ltd, AccuStandard, Dr Ehrenstorfer GmbH, Ningbo Huajia Chemical Co Ltd are the top players in Hexamethylphosphoramide Market.
Europe is expected to hold the highest market share in Hexamethylphosphoramide Market.
Oxidant Segment is expected to be the leading segment in Hexamethylphosphoramide Market during the forecast period.
Call us, email us, or chat with us! We encourage your questions and feedback. We have a research concierge team available at all times and included in every purchase.
We will send you an email with login credentials to access the report. You will also be able to download the pdf.
Basically, choose Pay by Purchase Order when you are checking out. We will connect with you via email to set up your order.

Hexamethylphosphoramide (HMPA) refers to a colorless organic liquid medium ammonia flavor that is found to be soluble in both polar and non-polar solvents. It is a highly efficient organic catalyst that is responsible for the reversible-deactivation radical polymerization of methyl methacrylate. It is made from the reaction of dimethylamine and phosphorus oxychloride and is used as a polymer-solvent for various applications such as a laboratory solvent for organometallic and organic reactions, selective solvent for gases, and a stabilizer in polystyrene against thermal degradation.

Hexamethylphosphoramide helps in improving the selectivity of certain organic reactions. It can be used as an anti-corrosion agent of PVC and other kinds of chlorine, which contains resin products and coatings. It is also used as an ultraviolet inhibitor, gas chromatographic fixative, and rocket fuel additives for lowering the freezing point.

Apart from this, it is used in a variety of processes and applications, such as a solvent, chemosterilant, gas chromatographic fixative, and thermal stabilizer. It is used as a solvent to convert carboxylate salt into esters by reacting with alkyl halides. Esters are a chemical amalgamation between alkyl and a substitute for hydrogen of an acid. Some of the naturally obtained esters include oils, fats, and triglycerides, which have the least impact on the health of humans and are continuously in demand due to their high-performance and custom design versatility.

They are used in the industrial application sector and are in high demand in several niche markets. In addition to this, it is used as a chemosterilant for a number of insect pests and chemical mutagen as it causes reproductive sterility in an organism. It is used to control the economically destructive or disease-causing pests, which are done by either causing temporary or permanent sterility of one or both of the sexes. Furthermore, it is also used as a weathering solvent of polyvinyl chloride and polar solvent, which significantly affects the aging and low-temperature resistance of the agricultural films.

Growing Demand for Hexamethylphosphoramide in Solar Industry

Solar energy is the most convenient renewable solution and a highly efficient form of unconventional energy that reduces greenhouse emissions and global warming. The solar industry has been growing rapidly, owing to the increasing environmental pollution and initiatives and support from various governments across the globe to install solar panels. Apart from this, the demand for solar energy systems is witnessing a significant surge in the power generation sectors. As per Solar Power Europe, solar energy alone reached a total share of 12.1% in the global total power output in 2017.

As per the Journal of Materials Chemistry, a 17% efficient perovskite solar mini-module was created with hexamethylphosphoramide (HMPA) as the lewis base additive. Perovskite solar cells convert visible light and ultraviolet into electricity. They also have tunable bandgaps, which means they can be easily custom-designed and hexamethylphosphoramide has helped in forming a denser and uniform perovskite film with high optoelectronic quality. 

Use of Hexamethylphosphoramide in PVC

The increased use of PVC in different industries is anticipated to surge the demand for hexamethylphosphoramide during the forecast period.

PVC refers to a very durable and long-lasting material, which falls into the category of thermoplastic resins that are hard plastics but can be softened through heating. It is made of 57% chlorine and 43% carbon and uses more renewable resources for its production. PVC is the world's third-most widely produced synthetic plastic polymer that is versatile, durable, affordable, and recyclable. It is used for a broad range of applications, such as window frames, cables, sports equipment, pipes, flooring, furniture, and a range of life-saving medical devices.

Hexamethylphosphoramide acts as the light stabilizer of PVC, which enables amazing anti-aging properties of outdoor products and excellent weather resistance. Thus, the use of hexamethylphosphoramide in PVC is increasing, further increasing the demand for PVC in various industries for its various advantages. As per the European Council of Vinyl Manufacturers, around 70% of the PVC is used for durable, affordable, and recyclable building and construction products. The council also stated that in the EU-28, about 6.5 million tons of PVC products are manufactured every year, further driving the demand for hexamethylphosphoramide.

Toxic Effects of Hexamethylphosphoramide

The carcinogenic solvent of hexamethylphosphoramide hinders the market growth. The researchers are compelled to look for better options, such as DMI, due to safety reasons. As per the Journal of Chemical Ecology, 19 out of 21 carcinogens are active in HMPA, whereas 3 out of 6 non-carcinogens were active in the Drosophila system.

Hexamethylphosphoramide is known to have toxic effects on experimental animals. The repetitive application of hexamethylphosphoramide on the skin of rabbits leads to weight loss, neurological disorders, and changes in gastric functions. Additionally, it initiates acute poisoning in rats leads to severe bronchiectasis and bronchial pneumonia. The oral administration of this liquid can cause semen deficiencies and testicular atrophy.

According to various studies, it has also been seen that upon inhaling HMPA, the rats start showing nasal tumors after eight months after getting exposed to 400 to 4000 ppb HMPA. In some of the mice, cancer has also been shown to be initiated. Therefore, the use of hexamethylphosphoramide on animals may get restricted in the near future.

Regional Overview

Growing Use of Polyvinyl Chloride in Europe Drive the Hexamethylphosphoramide Market

Europe holds the largest share in the hexamethylphosphoramide market on account of the growing use of polyvinyl chloride or PVC, which uses hexamethylphosphoramide to enable amazing anti-aging properties of outdoor products with excellent weather resistance.

As per the European Council of Vinyl Manufacturers, around 771,000 tons of PVC gets recycled each year, and the annual European consumption of PVC totals 5 million tons, which is 10% of all the plastics used in Europe. In addition to this, the increasing demand for plastics in various industries boosts the demand for PVC and hexamethylphosphoramide. As per the European Plastic Converters, the plastics industry makes a considerable contribution to the welfare in Europe by creating a turnover of 308.93 USD billion annually.

The burgeoning solar sector in this region propels the market growth of hexamethylphosphoramide as these are used in converting visible light and ultraviolet into electricity. According to Solar Power Europe, the solar power generation share increased to 48% compared to 42% in 2018. The sector saw an increase in the growth by 13% to 116.9 GW, marking a new annual installation record in 2019 over 8.2 GW in 2018.

Burgeoning Renewable Energy Sector in North America to Surge the Demand for Hexamethylphosphoramide in North America

The surging renewable energy sector primarily drives North America's hexamethylphosphoramide market. Hexamethylphosphoramide is used for the manufacturing of an efficient perovskite solar mini-module to generate electricity. As per the report shared by the U.S. Energy Information Administration, Monthly Energy Review, April 2020, the consumption of renewable resources, such as biomass, solar, geothermal, and wind energy, in the U.S. was three times greater in 2019 than in 2000. This shows that the country is working towards bringing a change in the consumption of renewable resources.

As per the National Renewable Energy Laboratory, the U.S. PV market was the second-largest in terms of both cumulatively and annual installations in 2018, which signifies the rapid growth of the solar industry. Moreover, the growth of the pharmaceutical sector in this region is projected to boost the demand for hexamethylphosphoramide due to the surging use of PVC in medical devices, which are expected to grow in the coming years.

Key Players

  • BASF SE
  • Masuda Chemical Industries Co Ltd
  • Alfa Chemistry
  • CarboMer
  • Apollo Scientific Ltd
  • AccuStandard
  • Dr Ehrenstorfer GmbH
  • Ningbo Huajia Chemical Co Ltd
  • Jiangxi JixiangPharmchemical Chemical Co Ltd.
  • Jinan FuFang Chemical Co Ltd

Hexamethylphosphoramide Market: Segmentation

By Type

  • 0%–99.5%
  • >99.5%

By Form

  • Specialty Solvent
  • Oxidant

By Region

  • North America
  • Europe
  • Asia-Pacific
  • Central and South America and the Caribbean
  • The Middle East and Africa

Frequently Asked Questions (FAQs)

Growing demand for hexamethylphosphoramide in solar industry, increased use of PVC in different industries are the key factors expected to drive Hexamethylphosphoramide Market during the forecast period.
BASF SE, Masuda Chemical Industries Co Ltd, Alfa Chemistry, CarboMer, Apollo Scientific Ltd, AccuStandard, Dr Ehrenstorfer GmbH, Ningbo Huajia Chemical Co Ltd are the top players in Hexamethylphosphoramide Market.
Europe is expected to hold the highest market share in Hexamethylphosphoramide Market.
Oxidant Segment is expected to be the leading segment in Hexamethylphosphoramide Market during the forecast period.
Call us, email us, or chat with us! We encourage your questions and feedback. We have a research concierge team available at all times and included in every purchase.
We will send you an email with login credentials to access the report. You will also be able to download the pdf.
Basically, choose Pay by Purchase Order when you are checking out. We will connect with you via email to set up your order.