Global Statistics Representing 3D Cell Culture Market Scenario
3D cell culture systems are witnessing huge popularity in drug discovery and tissue engineering as it provides physiologically relevant information and accurate data for in-vivo experiments. Its main function is to mimic the biological environment in in-vitro so that the cells are in a more comfortable environment to grow, differentiate, and function. It is extensively used in the treatment of organ transplantation, tumor cell differentiation in cancer, stem cell research, and drug testing. It also helps to study fluid dynamics and nutrient transport across the surrounding cellular environment or tissues.
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3D cell culture market was valued at USD 0.8 billion in 2019 and is expected to reach USD 2 billion by 2026 at a CAGR of 15%.
3D cell culture is a Multifaceted Technology
In the last few years, 3D cell culture has been witnessing significant demand in organ transplantation and cancer research activities, stem cell research, and drug testing and toxicity studies. Additionally, it is gaining huge popularity in the research institutes, pharmaceutical companies, biotech industries, clinical research laboratories, and hospitals as it offers umpteen benefits and eliminates the use of animals. For the record, 3D cell culture technology was developed at Berkeley Lab in 1980 to study the signaling pathways in breast cancer and to create an in-vitro culturing model in order to evaluate cellular responses to various pharmaceutical drugs. It is extensively used in the pharmaceutical and biotech sectors for studying the cellular vascular system, observing phenotypic changes in the cell, learning cell communication and interaction in tissues, and observing how cells migrate, differentiate, survive, and grow. Moreover, the paradigm shift from 2D to 3D culture as it offers a higher degree of structural complexity similar to tissues and organs provides accurate predictions of drug efficacy and toxicity and aids in understanding drug mechanism.
The global 3D cell culture market is segmented into products, applications, and end-user.
By product, the market is segmented into scaffold-based 3d cell cultures, scaffold-free 3d cell cultures, microfluidics-based 3d cell cultures, and magnetic & bio-printed 3d cell cultures. The scaffold-based 3d cell cultures are trifurcated into hydrogels, solid scaffolds, and micropatterned surfaces. The hydrogels segment is dominating the market due to its user-friendly nature and easy availability. Recently, Thermofischer scientific ltd. developed AlgiMatrix 3D Culture System. It is extensively used in regenerative medicine and preclinical in-vitro testing due to its biocompatibility, versatility of chemistry, and biological properties, which are significant in the application of tissue engineering and organ substitution.
In scaffold-free 3d cell cultures, the low attachment plates segment is expected to grow at a significant rate. It is popularly used in stem cell differentiation and cytotoxicity research. The microfluidics-based 3d cell cultures are grabbing one of the highest shares in the 3D cell culture market due to its growing demand in the biopharmaceutical sector.
By application, the 3D cell culture market is segmented into cancer & stem cell research, drug discovery & toxicology testing, and tissue engineering & regenerative medicine. Cancer and stem cell research segment is grabbing the largest share in the market due to the rapidly growing prevalence of cancer across the globe, which is further boosting stem cell research in several clinical applications. The drug discovery & toxicology testing segment is expected to witness significant growth due to the increasing adoption of personalized medicines in the medical sector for the treatment of a number of diseases.
By end-users, the market is segmented into pharmaceutical & biotechnology companies, research Institutes, and cosmetics industries. The segment is majorly driven by the stability and long lifespans of 3d cell culture models, rising government funding, and the increasing prevalence of cancer.
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Key Alternatives to Animal Testing
3D cell culture technology is extensively used for new drug development, deformity restoration, and regenerative medicines. It eliminates the use of animals, which is further lifting the pressure adhered by animal activists on the manufacturers. Some of the factors driving the market growth include the support from regulatory bodies regarding the approval of in-vitro tests, low costs in-vitro toxicology testing, advancements in in-vitro methodologies, tissue engineering, and organ transplantation, and assessment of drug efficacy and toxicity.
Regionally, the global 3D cell culture market is segmented into North America, Europe, Asia Pacific, and the Middle East and Africa.
North America is dominating the 3D cell culture market and will continue the same during the forecast period. This can be attributed to the increasing expenditure on research activities in the field of molecular and cell biology, advancements in regenerative medicine, increasing demand for cell-based research, and rising demand for monoclonal antibodies and biologics for the treatment of various diseases.
Europe is second in the 3D cell culture market on account of increasing R&D activities in biotechnology for drug discovery and evaluation, growing demand for advanced biologics and bio-similar produced by biopharmaceutical manufacturers, and increasing demand for innovations in the cell culture equipment and consumables for better productivity. In Germany, the market is expected to witness significant growth due to rising investment by key players and growing funding from government organizations in the field. Whereas, in the U.K and France, the growth in life science and biotech industries is expected to drive the market growth.
Asia-Pacific is the fastest-growing 3D cell culturing market in terms of revenue. The region is backed with the presence of leading countries in the market, such as India, Japan, China, South Korea, Australia, and New Zealand. In South Korea, the rising R&D activities are subsequently increasing the demand for stem cell therapies and regenerative medicine, which is further boosting the market growth. In September 2017, the Cell Therapy World Asia summit 2017 was held in the country, where several cell therapy companies gathered to discuss the best practices & innovations. In India and China, rising government support and strategic investments by key players in the biotechnology sector and life science are driving the market. Similarly, Japan is expected to witness considerable growth on account of increasing R&D activities and the continuous launch of new products. In 2014, Reprocell acquired Reinnervate Ltd. to accelerate the research activities in scaffolding structures in university laboratories. Additionally, the government of Japan is adhering to the extensive focus on cell-based regenerative medicine to encourage the development in 3D cell culture technology, which is further adding fuel to the market growth.
South America is expected to gain momentum in the years to come due to increasing awareness regarding 3D cell culture, which is gradually rising the demand for 3D cell culture in the region. In Brazil, the development in the healthcare sector and the presence of leading players are driving the market growth. Additionally, the government is actively working to facilitate the development of regenerative medicines in Brazil. For the record, the world's largest clinical trial in stem cells have also been conducted in Brazil. The country has established eight Cell Technology Centres (CTCs) dedicated to producing stem cells for research and clinical trials, which is further driving the market growth.
The Middle East and Africa
In Africa, the prevalence of cancer, malaria, and tuberculosis is increasing at an alarming rate. In 2018, newly reported cases of cancer increased by 10% as compared to 2011, which is boosting the need for cancer drug screening in the region. However, the governments and key players are arduously working to attend to the situation with the utmost efficiency. For instance, Netcells Biosciencesa has banked blood stem cells for over 5000 patients. Similarly, Cryo-Save launched a campaign in the country to educate the gynecologists about the benefits of stem cell preservation, which is further boosting the market growth to some extent.
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Some of the key players in the 3D cell culture market include Thermo Fisher Scientific, Corning Incorporated, Merck KGaA, Lonza Group, REPROCELL, 3D Biotek LLC, Emulate, Inc., CN Bio Innovations Limited, Hamilton Company, Insphero AG, Kirkstall, Ltd., MIMETAS BV, TissUse GmbH, Synthecon Incorporated, QGel SA, Greiner Bio-One International GmbH, Promocell GmbH, Advanced Biomatrix, Inc., Hrel Corporation, and Synvivo, Inc.
Thermo Fisher Scientific is a leading player in the market for 3D cell culture as it has established a strong brand identity and diverse product portfolio. To maintain its leading position, the company is adhering to extensive focus on R&D activities and new product launches. It is also adopting several growth strategies such as acquisitions and expansions for the same. For example, in October 2018, Thermo Fisher Scientific acquired Advanced Bioprocessing to expand its geographical reach.
Corning is a leading manufacturer of cell culture products, which include Corning spheroid microplate, Organotypic Tissue Models, Natural and synthetic hydrogels, and Corning Matrigel matrix. The company is performing extensive research activities to sustain in the raging competition. Recently, it launched a number of 3D nanofiber technology products, including microplates and tissue culture dishes.
The global 3D cell culture market is fragmented in nature. Several large and small-scale players are focusing on price, brand, and new product development to expand their consumer base. Some of the key players are engaging in acquisitions, collaborations, and partnerships to gain a competitive edge. For instance, in October 2018, Thermofische acquired Advanced Bioprocessing for USD 477 million to expand its geographical reach. Similarly, 3D Biotek, one of the market leaders in the 3D cell culture market, formed a strategic partnership with Megahill Corporation to perform extensive research in the field.
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