June 2026 Siegfried announced the construction of a large-scale drug substance manufacturing facility in Minden, Germany, adding approximately 100 m³ of reactor capacity to support complex pharmaceutical APIs, including sterile injectable products such as bupivacaine.
March 2026 Pfizer Hospital issued an emergency expiry date extension for selected Bupivacaine Spinal and Marcaine Spinal injection products to help maintain the availability of critical anesthetic supplies during temporary supply constraints.
October 2025 Cambrex announced a USD 120 million investment to expand its U.S. active pharmaceutical ingredient (API) manufacturing capabilities. The expansion is expected to strengthen domestic production capacity for injectable pharmaceutical ingredients, including those used in bupivacaine formulations.