01 The American Cancer Society's "Cancer Facts & Figures 2025" report provides projections for the United States. It estimates that in 2025, there will be over 2 million new cancer cases and more than 618,000 cancer deaths in the U.S. The WHO and other research bodies have made projections for the coming decades based on current trends. For example, some projections estimate that if current trends continue, the number of new cancer cases could rise to over 33 million and deaths to 18 million by 2050. The survival rates are currently the lowest due to improper healthcare infrastructure and a lack of awareness among people in these countries. As a result, cancer cachexia, characterized by systemic inflammation, a negative protein, energy balance, and an unintentional loss of lean body mass, is more common in cancer patients due to the high incidence of malignancies globally.
September 2025 Axcella Therapeutics expanded research activities around metabolic and muscle health applications, supporting the development of targeted approaches for conditions involving muscle loss and impaired energy metabolism, including oncology-related wasting disorders.
July 2025 Actimed Therapeutics advanced its lead investigational therapy S-pindolol benzoate (SLV-337) for cancer cachexia, progressing clinical development of treatments designed to address muscle wasting and functional decline associated with the condition.
June 2025 Helsinn Healthcare expanded its oncology supportive care portfolio through continued development and commercialization initiatives focused on improving quality of life for cancer patients, including management of cancer-related symptoms such as appetite loss and weight decline.
May 2025 Astellas Pharma expanded its oncology supportive care pipeline by advancing development programs targeting cancer cachexia and cancer-related metabolic disorders, strengthening its focus on therapies addressing unmet needs in patients with advanced cancer.