February 2026 AstraZeneca announced the initiation of a global Phase III clinical study evaluating Fasenra (benralizumab) in patients with eosinophilic granulomatosis with polyangiitis (EGPA), expanding its late-stage immunology pipeline for rare eosinophilic diseases. The study aims to assess the therapy's efficacy in achieving sustained remission and reducing corticosteroid dependence. (Company clinical trial announcement/clinical trial registry.)
September 2025 Nippon Shinyaku Co., Ltd. announced that the U.S. FDA granted Fast Track Designation to NS-229, its investigational selective JAK1 inhibitor for the treatment of eosinophilic granulomatosis with polyangiitis (EGPA). The designation is intended to accelerate the development and regulatory review of therapies addressing serious diseases with unmet medical needs.