The global nanopore technologies market size was valued at USD 203.16 million in 2021, presumed to reach USD 597 million, expanding at a CAGR of 14.41% during the forecast period. The biopolymers' sequencing, including polynucleotides in the form of DNA or RNA and other components, is done using a third-generation nanopore sequencing technique. Without the requirement for PCR (polymerase chain reaction) amplification or chemical tagging of the sample, single molecule DNA or RNA can be sequenced using nanopore sequencing technology. Additionally, this sequencing can provide substantially less expensive genotyping, increased testing mobility, and rapid sample processing with the capacity to display results in real-time. One of the most recent generations of sequencing technology, which aids in figuring out the nucleotide sequence in DNA or RNA, is used to determine the order of the nucleotides. Utilizing this technology, it is possible to decide on the sequence of a specific nucleic acid by tracking changes in an electric current while a molecule moves through a nanopore.
It is projected that increased innovation and development in nanopore technology would enable employing them to treat new viruses throughout the forecasted time. During the forecasting period, the market for nanopore technologies would benefit from increased DNA sequencing demand for various research applications. The market would also benefit from an increase in the usage of epigenetics to develop newer treatment approaches. Because sequencers can be quickly connected to other technological systems and will make it easier for healthcare professionals to monitor DNA samples in shared cloud computing labs, the introduction of the Internet of Things benefits nanopore technology. It is expected to support market growth over the forecast period.
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The Increased Research & Development Made on Nanopore Technologies
Research and development in the area of nanopore technology have seen sharp growth. Biological and solid-state nanopore sensors are technologies for detecting single molecules in the next generation. Nanopore technologies demonstrate label-free sensitivity, quick sequencing detection, and low cost. But, these technologies struggle to produce solid-state nanopores that are as high-quality as their biological counterparts. A lipid bilayer membrane contains ion and bacterial toxin channels, which operate as nanopore sensors with improved signal repeatability and high sensitivity. The market will make more money if studies and research into nanopore technologies increase.
Increased throughput of the instrument is due to increased precision with which the DNA sequence goes through the protein nanopore and a speed increase for DNA. Since throughput has grown, it is now possible to sequence larger genomes with good coverage, including the human genome. The nanopore technologies market is expected to gain traction in the upcoming years thanks to significant companies' focus on introducing more modern instruments and consumables to fulfill market demand.
The Demand for DNA Sequencing
Due to the rise in demand for DNA sequencing for various applications, nanopore technologies are anticipated to gain traction during the projected period. Additionally, nanopore sequencing has benefits across the board for research. For instance, real-time nanopore reading can be included in any workflow for assessing biological samples when quick and precise results are needed. RNA and DNA can be processed using nanopore sequencing, which can handle lengthy nucleic acid molecules. The increase in nanopore technology would aid the market's growth during the projection period because the generated readings commonly exceed 20 kb in length.
Additionally, these technologies can potentially change environmental analysis, disease identification, and laboratory and field detection of harmful algal blooms (HABs). Furthermore, nanopore detects structural variants (SVs) that are difficult to find with short reads and has low error rates for genotyping haploid single nucleotide variants (SNVs). Nanopore sequencing will speed up the monitoring of the malaria genome and offer fresh perspectives on the biology of the parasite genome. Therefore, these reasons increase the need for nanopore technologies, furthering market expansion.
The Maintenance Nucleotide Bases Integration
Maintaining the structure of nucleotide bases is the fundamental difficulty in nanopore sequencing. Research and investigation are still being done to determine the underlying principles and properties of polynucleotide translocation through pores. To identify the device that can be utilized for highly rapid DNA sequencing, nanopores must overcome hurdles in basic research and fundamental understanding of the issue. The goal is to create a device with all the necessary parts and insert nanoelectrodes into the proper pores. The nanopore technologies market expansion is hampered by the lack of precise devices that can aid in nanopore sequencing and difficulties maintaining the integrity of nucleotide bases.
The Use of Nanopore Technologies in Fourth Generation DNA Sequencing
The entire human genome might be quickly and accurately sequenced using nanopore-based sequencers, the fourth-generation DNA sequencing method, for less than USD 1000 and perhaps even less than USD 100. This technology’s single-molecule method enables further investigation of the interactions between proteins, DNA, and other proteins. A new avenue for single-molecule molecular biology research is made possible by nanopore analysis. The nanopore method is one of the choices for the fourth-generation quick and inexpensive DNA sequencing technology. Thus, it is projected that all of these variables working together would present profitable prospects for the growth of the global nanopore technologies market throughout the forecast period.
The global nanopore technologies market is classified based on product, application, end-user, and region.
Based on product, the segments include Instruments and Consumables.
The consumables section is projected to advance at a CAGR of 15.1% and hold the largest market share. Nanopore technologies require a variety of consumables, including flow cells, sample preparation kits, sequencing kits, expansion packs, and equipment for DNA and RNA sequencing. Increased demand for consumables has increased the revenue share produced by this segment. Additionally, the industry is expected to rise because of advancements in consumables that make it easier to sequence altered or complex structures. Additionally, various consumables are offered for kits for identifying sequencing, direct cDNA sequencing, field sequencing, 16S barcoding, Cas9 sequencing, and ultra-long DNA sequencing.
The instruments section will hold the second-largest share. Nanopore technologies are carried out using tabletop and portable instruments. The mobility and ease of use of portable devices will undoubtedly benefit from advancements in such fields. Additionally, portable gadgets are made to work with cellphones and other mobile, low-power gadgets. Additionally, cutting-edge equipment is employed for field-based analyses and possible applications like remote pathogen monitoring in an infectious disease outbreak.
Based on application, the segments include DNA sequencing and RNA sequencing.
The DNA sequencing section is projected to advance at a CAGR of 14.81% and hold the largest market share. A, C, G, and T nucleotides in a DNA molecule can be precisely identified via DNA sequencing. The cell's information to form protein and RNA molecules is included in the DNA base sequence. Scientists examining the functioning of genes need to know the DNA sequence. Long DNA fragments can now be directly and instantly analyzed thanks to the novel, scalable nanopore sequencing technology. It functions by watching how electrical current changes as nucleic acids travel through a protein nanopore. The precise DNA sequence is obtained by decoding the resulting signal.
The RNA sequencing section will hold the second-largest share. Using RNA sequencing, it is possible to determine the amount and distribution of RNA in a biological sample. It also examines the constantly evolving transcriptome of the cell. It is known that complex viral transcriptomes can be characterized by using traditional RNA sequencing methods, which are challenging because of high gene density, overlapping reading frames, and complex splicing patterns. Additionally, direct RNA sequencing employing nanopore arrays provides a better alternative since it allows for the direct sequencing of individual polyadenylated RNAs without the recording and amplifying bases in other sequencing technologies.
Based on end-user, the segments include hospitals & clinics, research institutes, and others.
The research institutes section is projected to advance at a CAGR of 14.02% and hold the largest market share. An organization established specifically to conduct research is known as a research institute. Research institutions may occasionally be focused on applied research or specialize in basic research. Numerous research organizations are concentrating on studies to employ nanopore technology for various purposes, including identifying novel viruses that are mutating and forming and are the root cause of numerous diseases. Viral disease incidence has seen a sharp increase, which is expected to increase the need for research institutes to concentrate on creating methods for more effective treatment of such viral diseases.
The other section will hold the second-largest share. Companies in the pharmaceutical and biotechnology industries, academic and governmental institutions, and other similar businesses concentrating on creating cutting-edge nanopore technologies make up the other section. Governmental entities receive funding and investments for advancing technology to continue studying topics connected to medicines and diagnostics.
The region-wise segmentation of the global nanopore technologies market includes North America, Europe, Asia-Pacific, and LAMEA.
North America and Europe Will Dominate the Regional Market
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North America will command the market with the largest share while growing at a CAGR of 13.91%. One significant element influencing the growth of the nanopore technology market is the presence of substantial important players in North America, such as Oxford Nanopore Technologies and ONTERA, Inc. Additionally, the rise in viral infections like the coronavirus and the Ebola virus, as well as the availability of cutting-edge healthcare facilities with qualified medical staff, all significantly contribute to the expansion of the North American market. Additionally, the market's growth is mainly related to the rise in demand for improved healthcare services, accompanied by more lavish healthcare spending and technological developments in nanopore technology.
Europe will expand at a CAGR of 14.61% and hold USD 195 million. The rapid development of nanopore technologies, the rise in viral disease incidence, and the region's soaring need for new technologies all contribute to expanding nanopore technologies in Europe. The increased demand for healthcare services and the rise in hospitalizations and drug expenses place a significant social strain on European budgets. Hospitals in Europe are spending more money on products and technology due to the increase in viral diseases requiring nanopore technology to identify the virus' DNA. This subsequently fuels the market expansion in this region.
Additionally, the market is expected to develop as more healthcare professionals use nanopore technology to analyze viral genomes. Further, the European market is being driven by new product breakthroughs in nanopore technologies and an increase in the prevalence of viral infections. The presence of established infrastructure in the healthcare sector and the accessibility of qualified personnel are other factors that significantly contribute to the expansion of the Europe nanopore technology market.
List of nanopore technologies market companies profiled