Organoids and Spheroids Market Size & Outlook, 2025-2033

Organoids and Spheroids Market Size

The global organoids and spheroids market size was valued at USD 1.90 billion in 2024 and is projected to reach from USD 2.04 billion in 2025 to USD 3.55 billion by 2033, growing at a CAGR of 7.2% during the forecast period (2025-2033).

Model systems drive biological research by mimicking processes and functions of the body from the molecular to the whole organism level. Organoids and spheroids are cells cultured in three dimensions. By deeper insights, spheroids are often grown from cancer cell lines or tumor biopsies as freely floating cell aggregates in ultra-low attachment plates. In contrast, organoids are derived from tissue stem cells embedded within the matrix. These 3D models find extensive usage in modern means of clinical trials as well as personalized medicine regime.

The recent coronavirus outbreak has surged the usage of the organoid models to study and reveal the COVID-19 virus mechanism, affecting several intestinal cells. Many scientists have already begun using these systems for the testing and identification of promising medications. Further, companies engaged in the development and launch of products are stepping up in the arena.  For instance, Agilent Technologies developed and launched a microplate, Seahorse XFe96 Spheroid Microplates that facilitates cellular energy metabolism measurement in 3D cell culture spheroids with the help of a Seahorse XF analyzer.

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Market Dynamics

Technological Developments and Innovations in 3d Spheroid Technology to Drive the Market Growth

Technological interventions, as well as the latest innovations, coupled with 3D model technologies, drive the market growth. For instance, the Cultrex Organoid Progenitor Cells launched by AMS Biotechnology (AMSBIO) can be optimized using different sets of extracellular matrices, facilitating the researchers to direct the cellular activities by controlling the culture micro-environment. Thus, spheroids produced by this technique are used for the modeling of cell invasion from tumor spheroids.

Researchers have further developed a 3D tri-culture model by adding vascular cells and human mesenchymal stem cells (hMSCs) to these spheroids. These efforts have led to the development of a predictive in-vitro model as the tri-cultures exhibit drug response and tumor morphology similar to xenografts. Such studies have propelled the adoption of spheroids and organoids in drug testing and clinical trials.

Rapid acceptance and utilization of spheroid and organoid culture in government-based research bodies, as well as institutional projects, is expected to drive the academic and research institutes segment. One such example is researchers from the Stanley Center for Psychiatric Research (Broad Institute) and Harvard University that created enhanced human brain organoids in June 2019 to strengthen neurological disorder research.

Regional Analysis

North America to Hold the Lion’s Share in the Organoids and Spheroids Market

The rapid rise in the implementation of organoid-based research models in the biotechnology sector of the U.S. and Canada drives the regional market growth. These 3D culture technologies have helped the researchers to overcome restraints faced by 2D cell culture platforms, as 3D spheroids offer a microenvironment that can mimic the properties of human tissue structures. Moreover, the presence of numerous state and federal funding organizations in this region that are motivated to fund such projects is also expected to drive the demand for organoids and spheroids culture systems. For instance, a February 2020 study conducted by the American Association for the Study of Liver Diseases (AASLD) regarding the usage of organoid medicine in hepatology was supported by the AASLD Foundation (Pinnacle Research Award), North American Society of Gastroenterology Hepatology and Nutrition Foundation, and Cincinnati Children’s Research Foundation (Procter Scholar Award).

Segmental Analysis

Spheroids Segment to Dominate the Market Based on Rising Its Rising Demand in Cancer Research

In the past few years, spheroid cultures have been witnessing ever-growing demand in the field of drug discovery, toxicology, and cancer research. This is attributed to the fact that spheroids have a similar development pattern as of tumors, and they can be cultured to produce a huge volume of cells with consistent dimensions. They can also be analyzed and counted by the use of a variety of instruments and techniques.

The multicellular tumor spheroids (MCTS) segment, on the other hand, dominates the spheroid segment as it is the most commonly adopted spheroid model for cell culture. In April 2020, a study conducted by researchers of the University of Pittsburgh showed the utilization of MCTS in preclinical cancer drug studies. The study concluded that the utilization of MCTS in oncology drug screening regimes can lead to a better assessment of drug response and give accurate insights.

organoids Segment is Expected to Grow with the Highest Cagr

Organoids can potentially be used as in-vitro models for drug discovery. With developments in the organoids segment, the market is expected to garner higher revenue during the forecast period. For instance, MatTek Corporation cultured 3D organotypic structures for the production and commercialization of in-vitro human tissue models. The company has commercialized a diverse product portfolio of bronchial airway (EpiAirway), skin (EpiDerm, EpiDermFT), vaginal (EpiVaginal), and ocular (EpiOcular) epithelium.

The intestinal organoids segment holds the largest share in the organoid segment on account of the increasing availability of commercial model systems and intestinal epithelium analysis methods. In addition, intestinal organoids find applications in the field of cell biology, modeling of diseases, and production and screening of drugs.

biology Segment to Dominate the Market during the Forecast Period

The biology segment dominates the market during the forecast period. Organoid biology provides a great opportunity to test the basics of human developmental biology, learned through classical methods. In the study of the tissue homeostasis process, lineage determination, and embryonic growth, organoids derived from Induced Pluripotent Stem Cells (iPSCs), and Embryonic Stem Cells (ESCs) have proven to be beneficial. This is because the characteristics of the developmental stages they go through are preserved by organoids. Therefore, these models have been used for the study of the stomach, pancreas, and brain developmental biology.

Collaboration and Strategic Partnerships to Drive the Biotechnology and Pharmaceutical Companies Segment

The biotechnology and pharmaceutical companies segment accounted for the largest market share. Future therapeutic applications of organoids and spheroids have motivated pharmaceutical startups to adopt these products. In addition, the surging use of organoids and spheroids by pharmaceutical entities in preclinical drug discovery is expected to propel segment growth. Further, the collaborations and strategic alliances between key players provide an impetus to the market growth. In October 2019, Hubrecht Organoid Technology (HUB) collaborated with MIMETAS to commercialize Organoids-on-a-Chip technology.

List of key players in Organoids and Spheroids Market

1. 3D Biomatrix (The U.S.)
2. 3D Biotek LLC (The U.S.)
3. AMS Biotechnology (Europe) Limited (U.K.)
4. ATCC (The U.S.)
5. Cellesce Ltd.
6. Corning Incorporated (The U.S.)
7. Greiner Bio-One (The U.S.)
8. Hubrecht Organoid Technology (HUB) (the Netherlands)
9. Kuraray (Japan)
10. Lonza (Japan)
11. Merck KGaA (The U.S.)
12. Thermo Fisher Scientific, Inc. (The U.S.)

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Recent Developments

• In 2020, researchers developed mini lungs using 3D cultured models to study the mechanism of the entry of SARS-CoV-2 and its spread in tissues. Organoids have also been employed to study the defense mechanism of tissues against SARS-CoV-2
• SCIVAX Corporation developed the Nano Culture Plate (NCP) and Nano Culture Dish (NCD). Spheroids grown on NCP can be used for live imaging under both fluorescence and bright-field microscopes.