Chromatography is a laboratory and analytical technique used to separate a mixture by allowing it to flow through a medium and then separating it into individual components depending on their flow rates. Preparative or purification chromatography is described as the process of using chromatography to segregate an individual compound in the desired quantity and at a purity level sufficient for further experiments or processes.
The preparative and process chromatography market is expected to grow with a CAGR of 6.7% during the forecast period.
According to the International Diabetes Federation, in 2019, approximately 463 million adults are living with diabetes, and by 2045 the number will rise to 700 million. There is a rising demand for insulin as the amount of insulin needed to effectively treat type 2 diabetes would rise by more than 20 percent over the next 12 years. More than half of the population in China, India, and the U.S. within the age group of 20 to 79, are living with type 2 diabetes. These numbers are expected to soar up to more than 500 million by 2030 in these countries.
The overall cost of treatment for chronic diabetes depends on the cost of insulin. The financial burden for the treatment of diabetes is a challenge for all the healthcare systems around the world, even though insulin is a relatively low-priced drug, however, the chronic nature of diabetes leads to elevated cost for insulin treatment, and together with an increasing number of patients around the world creating a challenge to deal. Thus, a price reduction of insulin is needed to improve its availability especially in lower to lower-middle-income countries. Therefore, optimization of the purification chromatography is required to obtain a secure production of high purity insulin with maximum yield.
Therefore, the mounting diabetic population leading to rising demand for insulin is increasing the gravity of the situation for developing better and effective methods of extraction and purification chromatography. Thus, giving rise to the demand for chromatography and driving the market growth.
Omega-3 fatty acids are a group of polyunsaturated fatty acids that are required for certain vital functions and benefits in the human body, but the body cannot produce these fatty acids on its own, thus are required to source from outside in the form of a supplement. These Omega-3 fatty acids such as Alpha-linolenic acid (ALA) is important for the eye, nerve, and membrane development, whereas Eicosapentaenoic acid (EPA) and Docosahexaenoic acid (DHA) are significant for the production of prostaglandins, that help to regulate blood pressure, inflammation, neurological functions, hormones production, etc. in the human body.
A daily intake of 250 mg of Omega-3 per adult gives optimal protection against diseases such as coronary heart disease, also for children, 150 mg per day is enough for optimal brain development. Fish are the natural food source of omega-3 fatty acids. As people are becoming more health-conscious, there is an increased demand for supplements.
With the increased focus, research, and knowledge on the beneficial properties of these fatty acids, demand for omega-3 supplements has skyrocketed. Thus, extraction and purification chromatography gives the maximum yield for Omega-3 to meet the requirement. Therefore, driving market growth.
The aging population is projected to nearly double from 52 million in 2018 to 95 million by 2060. The 65-and-older age group's share of the total population will rise from 16% to 23% in the U.S. The elderly population is more prone to diabetes, cardiovascular diseases, etc. Resulting in an increased economic pressure on the public finances, which goes towards the health management of the aging population, placing stress on the redistribution of income from the young to the retired.
Japan is the biggest example of facing the problem of the aging population for putting forward secular stagnation in a country. Chromatography helps in the process of extraction and purification of important biopharmaceutical products with maximum yield such as insulin, supplements, monoclonal antibodies, etc., reducing the prices of these products and thus leading to relaxing the stress on the public incomes. Therefore, it is contributing to the growth of the market.
Monoclonal antibodies (mAb) are laboratory-produced molecules, designed to bind specifically with the cancer cells and engineered to serve as substitute antibodies that can restore or enhance the immune system's attack on cancer cells. Making it easier to identify a cancerous cell from healthy cells, which then can be treated or removed. According to WHO, cancer is the second leading cause of death globally and is responsible for an estimated 9.6 million deaths in 2018. Globally, about 1 in 6 deaths is due to cancer.
Size exclusion chromatography (SEC) is an important process used in the separation and purification of mAb, thus, leading to the increased demand for preparative and process chromatography, and boosting the growth of the market.
Based on the type, the global preparative and process chromatography market is majorly segmented into process chromatography and preparative chromatography.
The preparative chromatography segment accounted for the largest share of the preparative and process chromatography market. This segment's large share can be attributed to the applications of this type of chromatography in the pharmaceutical industry by providing them with the purified molecules by cleaning them of their impurities and maintaining the clinical supply of active pharmaceutical ingredients (API).
North America dominates the preparative and process chromatography market as the region is backed by a well-established healthcare system, high disposable income, high penetration, and adoption rate for biopharmaceutical products, increase in awareness for health-conscious, therefore, resulting in the increased demand for preparative and process chromatography. Moreover, the rising geriatric population leading to the surging prevalence of target diseases such as diabetes, cardiovascular diseases, etc. in the region is further anticipated to propel market growth.
According, the U.S. Department of Health & Human Services, in 2019, 34.2 million Americans have diabetes, and the number is growing. Besides, the local presence of key players such as Johnson & Johnson, Merck & Co., etc. is also one of the indicators that portray its current huge market potential.
Furthermore, lifestyle changes such as increased alcohol and tobacco consumption, absence of physical activities, inactive work life, and dietary habits which include high intake of saturated fats and sugars are observed among the adult population. These factors increase the risk of diabetes, cardiovascular and other diseases. Therefore, leading to the rising burden of target diseases is expected to boost the market in the forthcoming years. Thus, these factors contribute to accelerated regional market growth.
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