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Tangential Flow Filtration Market Size, Share & Trends Analysis Report By Type (Single-Use Tangential Flow Filtration Systems, Reusable Tangential Flow Filtration Systems, Filtration Accessories, Membrane Filters), By Technology (Ultrafiltration, Microfiltration, Reverse osmosis, Nanofiltration) and By Region(North America, Europe, APAC, Middle East and Africa, LATAM) Forecasts, 2025-2033

Report Code: SRAM1505DR
Last Updated : Oct 25, 2024
Author : Straits Research
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Tangential Flow Filtration Market Size

The global Tangential Flow Filtration Market size was valued at USD 2.55 billion in 2024 and is projected to reach from USD 2.85 billion in 2025 to USD 6.96 billion by 2033, growing at a CAGR of 11.8% during the forecast period (2025-2033).

More businesses are anticipated to enter the market as a result of the expansion of the market, which will increase competition and drive down prices. Furthermore, businesses may provide higher-quality products faster and at a cheaper cost as a result of improving their efficiency-focused technology and procedures. The market is expanding as a result of the growing need to purify biomolecules, such as viruses, proteins, and nucleic acids.

Tangential flow filtration (TFF) is a quick and effective purification procedure used in various branches of biology, including biochemistry, protein chemistry, immunology, and microbiology. The tangential flow filtration market incorporates a broad scope of TFF systems, including reusable and single-use systems, membranes, and accessories used in tangential flow filtration processes in the biopharmaceutical industry. A multifunctional tangential flow filtration (TFF) GMP system called FlexiPro TFF has been launched by Verdot in response to the growing industry need for gene therapy, vaccines, and mRNA-based therapies.

Tangential Flow Filtration Market

Tangential Flow Filtration Market Size

The pollution of biotherapeutics, water, and other laboratory constituents is discovered in laboratories, biopharmaceuticals, and biotechnology research centers. Subsequently, there is a steadily expanding interest in novel lab filtration methods broadly utilized by different research businesses. The biopharmaceutical and biotech ventures have grown significantly because of expanded production and R&D activities. This element gives the global tangential flow filtration market good chances to develop.

Tremendous progress has been made in recent years, including advances in continuous manufacturing and the versatility of single-use technologies. In any case, there has been a new shift towards continuous processing, which can increase the importance of in-line monitoring and the complexity of bacteria and other unnecessary particles for clearance and inactivation.

Besides, there is an essential requirement for improving new technologies that enable real-time confirmation of bacteria or virus inactivation, freedom to help process improvement, and assessing the impact of process deviations during manufacturing. As a result, filtration clearance studies are being carried out to confirm if the elimination steps are feasible. This is critical for the successful approval of biopharmaceutical research processes.

Tangential Flow Filtration Market Restraining Factors

The increasing number of new biologics, combined with biosimilar competition, is fueling global biologics demand. It necessitates the expansion of existing manufacturing capacities and the adoption of advanced technologies. However, high initial setup costs and biologics manufacturing are the primary factors impeding market growth, particularly in developing and underdeveloped countries.

As biologics are more sensitive than chemical drugs, they require more planning, investment, and experienced personnel to manufacture. To produce high-quality products, manufacturing must be carefully constructed and closely monitored. A large-scale facility, for example, will cost USD 200–500 million and take four to five years to build, whereas a small-scale facility will cost USD 30–100 million and take four to five years. 

Furthermore, biologics are temperature sensitive, prone to shearing and degradation, and are not as long-lasting as small molecules. Thus, companies in the biologics industry are outsourcing manufacturing to gain access to external expertise, technology, and capacity that would otherwise be unavailable in-house. This will ultimately raise the cost of finished goods and may stifle market growth. 

Biosimilars cost between USD 100 million and USD 200 million to develop and manufacture, while generics cost about USD 1 million to USD 5 million to produce. Well-established companies with manufacturing and commercialization experience have significant advantages over new and emerging companies. The high cost of process technologies and significant initial investment costs make it difficult for new biologic manufacturers to enter the market, further impeding the market growth.

Tangential Flow Filtration Market Opportunities

The global tangential flow filtration market is growing due to the expansion of the biopharmaceutical sector, rising pharmaceutical company funding, the increasing adoption of single-use technologies, and the benefits of tangential flow filtration. Tangential filtration techniques are used for various purposes, including downstream processing in bio-manufacturing, separation and purification of biomolecules, and upstream harvesting. 

Companies have introduced advanced and novel filtration techniques, such as tangential flow filtration, that the industry requires due to the allocation of resources for R&D activities. According to studies, ultrafiltration applications have increased in the last decade, which has increased demand for the same. Ultrafiltration membranes are currently in high demand in the industry, closely followed by microfiltration membranes.

Study Period 2021-2033 CAGR 11.8%
Historical Period 2021-2023 Forecast Period 2025-2033
Base Year 2024 Base Year Market Size USD 2.55 Billion
Forecast Year 2033 Forecast Year Market Size USD 6.96 Billion
Largest Market North America Fastest Growing Market Asia Pacific
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Regional Insights

North America: Dominant Region

As a technologically advanced country, the United States and US-based firms have implemented tangential flow filtration technology in various procedures and the drug manufacturing process. The United States leads the world in pharmaceutical R&D spending and is also the largest market for bulk drugs and finished dosage formulations. The US market is a free market economy. According to the Pharmaceutical Research and Manufacturers Association (PhRMA), US companies conduct more than half of the world's pharmaceutical R&D (USD 75 billion) and own the intellectual property rights to the majority of new medicines. Several high-performing and internationally renowned research facilities can be found in Canada. Further, the Canadian government recently invested in top research labs.

The bioprocessing industry in China is maintaining its momentum through ongoing investments in the life sciences and biopharmaceuticals sectors and the expansion of manufacturing capacity. Further, global biologics manufacturers keep a close eye on China because of the market opportunities for establishing manufacturing plants and expanding their businesses. This fuels the country's adoption of various types of filtration systems, such as tangential flow filtration. With the country's increasing pharmaceutical and biopharmaceutical manufacturing capacities, the Indian market for tangential flow filtration is being driven by a growing number of biologics manufacturers. India is expected to become one of the world's fastest-growing bioregions. Furthermore, a greater number of regional and global bioprocessing equipment manufacturers are expected.

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Segmental Analysis

By Application

The global market is divided into single-use tangential flow filtration systems, reusable tangential flow filtration systems, filtration accessories, and membrane filters. Filter membranes' growth can be attributed to their widespread use in biologics manufacturing and laboratory settings. Furthermore, the use of filter membranes in other industry verticals has led to advancements in membrane technology, increased operational efficiencies, and decreased membrane production costs, resulting in their increased adoption even in small operations.

Filter membranes are microporous plastic films with specific pore sizes that, primarily through surface capture, retain particles or microorganisms larger than their pore sizes. Membrane filtration technology is widely used in a variety of industries. Membrane filtration is commonly used in laboratories to remove particulates and contamination. Tangential flow filtration filter membranes can be used in microfiltration applications such as clarifying cells and cell lysates. They are used in ultrafiltration applications to concentrate diafiltration or recombinant proteins such as monoclonal antibodies.

By Technology

The global market is divided into ultrafiltration, microfiltration, reverse osmosis, and nanofiltration. Ultrafiltration (UF) is a type of membrane filtration in which pressure or concentration gradients cause separation through a semipermeable membrane. Suspended solids and high molecular weight solutes are retained, while water and low molecular weight solutes pass through the membrane. Ultrafiltration membrane pores can remove particles as small as 0.001–0.1 m from fluids.

This technology is preferred over other filtrations because of the consistent product quality, cost-efficiency, ease of operation, and lack of involvement of other chemicals. Ultrafiltration membranes are used to concentrate and fractionate protein streams and concentrate viruses, desalt, and exchange buffers.

Market Size By Type

Market Size By Type
  • Single-Use Tangential Flow Filtration Systems
  • Reusable Tangential Flow Filtration Systems
  • Filtration Accessories
  • Membrane Filters


  • List of key players in Tangential Flow Filtration Market

    1. Danner Corporation
    2. General Electric Company
    3. Merck KGaA
    4. Novasep Holding SAS
    5. Parker Hanifin Corporation
    6. Repligen Corporation
    7. Solaris Biotechnology SRL
    Tangential Flow Filtration Market Share of Key Players

    Recent Developments

    • April 2018: Merck KGaA introduced the Pellicon Capsule with Ultracel Membrane, a first-of-its-kind single-use tangential flow filtration device that advances flexible manufacturing.
    • October 2018: Merck KGaA has completed the acquisition of Intermolecular Inc.

    Tangential Flow Filtration Market Segmentations

    By Type (2021-2033)

    • Single-Use Tangential Flow Filtration Systems
    • Reusable Tangential Flow Filtration Systems
    • Filtration Accessories
    • Membrane Filters

    By Technology (2021-2033)

    • Ultrafiltration
    • Microfiltration
    • Reverse osmosis
    • Nanofiltration

    Frequently Asked Questions (FAQs)

    What is the estimated growth rate (CAGR) of the Tangential Flow Filtration Market?
    Tangential Flow Filtration Market size will grow at approx. CAGR of 11.8% during the forecast period.
    Some of the top prominent players in Global Marketare, Danner Corporation, General Electric Company, Merck KGaA, Novasep Holding SAS, Parker Hanifin Corporation, Repligen Corporation, Solaris Biotechnology SRL, etc.
    North America has held a dominant position in the Global Market, with the largest market share.
    The region with the most rapid expansion in the Global Market is Asia Pacific.
    The Global Market report is segmented as follows: By Type, By Technology


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