Home Biotechnology Bone Morphogenetic Protein Market Size, Share, Trends, Demand, Forecast by 2031

Bone Morphogenetic Protein Market

Bone Morphogenetic Protein Market Size, Share & Trends Analysis Report By Type (Recombinant Human Bone Morphogenetic Protein (rhBMP)-2, Recombinant Human Bone Morphogenetic Protein (rhBMP)-7), By Applications (Spinal Fusion, Trauma, Reconstructive Surgery, Oral-Maxillofacial, Others) and By Region(North America, Europe, APAC, Middle East and Africa, LATAM) Forecasts, 2023-2031

Report Code: SRBI54826DR
Study Period 2019-2031 CAGR 3.6%
Historical Period 2019-2021 Forecast Period 2023-2031
Base Year 2022 Base Year Market Size USD 459.09 Million
Forecast Year 2031 Forecast Year Market Size USD 607.78 Million
Largest Market North America Fastest Growing Market Europe
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Market Overview

The global bone morphogenetic protein market size was valued at USD 459.09 million in 2022. It is estimated to reach USD 607.78 million by 2031, growing at a CAGR of 3.6% during the forecast period (2023–2031).

Bone morphogenetic proteins (BMPs) are a cytokine that promotes bone and cartilage maintenance and development. Bone morphogenetic proteins are members of the superfamily of beta-super glycoproteins. It is helpful for spinal infusion therapy and is employed in various orthopedic applications, including spinal fusions and oral surgery. This is also used to treat renal disease and is named rh-BMP-7.

Bone morphogenetic factors also play a role in partially shaping other systems within the human body, not solely limited to the central nervous system. One of the main things pushing this industry forward is the rising number of minimally invasive treatments that include bone morphogenetic protein. The rising number of healthcare-related R&D projects is also expected to boost the global demand for bone morphogenetic proteins.


  • Recombinant Human Bone Morphogenetic Protein (rhBMP-2) dominates the product type segment
  • Spinal fusion dominates the application segment
  • North America is the highest shareholders in the global market

Market Dynamics

Global Market Drivers:

Increasing Incidence of Spinal Injuries and the Elderly Population

The spinal injury market is projected to experience growth in the upcoming years due to an increase in the incidence of spinal injuries and a corresponding rise in surgical procedures. Various manufacturing companies are conducting ongoing research to explore the therapeutic potential of BMP in different orthopedic disorders, such as soft tissue repair and osteoarthritis. This research is expected to increase the demand for the product.

Several factors, including the increasing incidence of spinal injuries, sedentary lifestyle, sport-related injuries, and poor posture, propel the bone morphogenetic protein market over the forecast period. Rehabilitation services and long-term care facilities must modify their approach to offer customized and all-inclusive care for the aging population suffering from spinal injuries. The process of restoring mobility, strength, and overall functionality may require the involvement of multidisciplinary teams, specialized equipment, assistive technologies, and rehabilitation programs.

Growing Research and Development

BMPs are a group of proteins that are very important for bone growth, tissue repair, and tissue growth. One area that BMP treatments focus on is orthopedics and diseases of the bones. Researchers are looking into how BMPs can speed up bone mending, help the spine fuse together, and improve the results of bone grafts. In addition, BMPs can encourage stem cells to turn into cells that make bone and speed up the mending process. This could mean patients do not need as much surgery and have better results. Tissue engineering and regenerative medicine are two more areas where BMPs are being studied. Researchers are looking into how they could fix and grow back other kinds of tissues, like cartilage, tendons, ligaments, and even organs.

Additionally, scientists want to find new ways to treat conditions like osteoarthritis, rotator cuff injuries, and tissue damage from accidents or diseases by using the ability of BMPs to cause tissue growth and remodeling. Researchers are looking into how well they help wounds heal, treat fractures that do not heal properly, and even treat some types of cancer. Research and development is done through in vitro studies, animal tests, and human trials. These studies aim to learn more about how BMPs work, find the best ways to give them, test their safety and effectiveness, and determine which groups of patients are best for BMP-based interventions. These factors drive bone morphogenetic protein market growth.

Global Market Restraints:

High Implementation Cost

Extensive research and development efforts are needed to create and refine BMP therapies. Understanding the mechanism of action, improving formulations, and performing preclinical and clinical trials all take time and money for scientists and researchers. Expensive resources are required to conduct tests, acquire materials and equipment, and support research teams engaged in such R&D operations. In addition, healthcare providers, insurance companies, and patients may face difficulties because of the high BMP market implementation cost. BMP therapies may be out of reach for those with limited financial resources or poor access to medical care because of their high price tags, restraining market growth.

Furthermore, concerns about cost negatively impact patient results and the widespread acceptance of novel BMP treatments. The BMP market is attempting to overcome its price barriers. Research is undertaken to find more efficient production techniques, investigate other distribution systems, and optimize treatment procedures to reduce costs. Moreover, technological developments, increasing market rivalry, and prospective regulatory changes may all shape future cost dynamics.

Global Market Opportunities

Rising Technological Development

Technological advancements have led to improved delivery methods for BMP treatments. These advancements enable more precise and controlled administration of BMPs, ensuring targeted delivery to the specific site where they are needed. For example, researchers have created biocompatible scaffolds, nanoparticles, hydrogels, and microencapsulation techniques that allow for slow and localized release of BMPs. These delivery tools enhance the regenerative potential of BMPs by providing a supportive environment for cell growth and differentiation, closely resembling native tissues.

Moreover, 3D printing technology enables the creation of intricate structures and customized implants for effective bone repair and regeneration. These advancements in delivery methods offer greater accuracy and regulation in BMP administration, enhancing their therapeutic outcomes.

Regional Analysis

Based on region, the global bone morphogenetic protein market is bifurcated into Asia-Pacific, North America, Europe, Latin America, and the Middle East and Africa.

North America Dominates the Global Market

North America is the most significant global bone morphogenetic protein market shareholder and is predicted to rise significantly during the forecast period. North America has a well-established and advanced healthcare system that includes top-notch hospitals, clinics, and research institutions. This robust infrastructure supports the adoption and utilization of innovative medical technologies like Bone Morphogenetic Protein (BMP) treatments. The presence of highly skilled healthcare experts and access to state-of-the-art facilities play a significant role in driving the growth of the bone morphogenetic protein market share in the region. In addition, the aging population in North America is rising, leading to a higher prevalence of age-related bone diseases and conditions. Older individuals are more susceptible to fractures and degenerative bone disorders, so the demand for BMP therapies becomes crucial for their care. This demographic trend is a strong driver for the growth of the BMP market in North America.

Additionally, North America is renowned for its leadership in biomedical research and development. The region has numerous prominent pharmaceutical and biotechnology companies, research institutions, and academic centers. These entities actively engage in advancing BMP formulations, delivery methods, and therapeutic approaches through intensive research and development efforts. This strong focus on R&D fosters innovation and propels the growth of the BMP market in North America. With the region's advanced healthcare infrastructure, high prevalence of bone-related disorders, aging population, robust research and development initiatives, favorable regulatory environment, and supportive reimbursement policies, North America presents a highly favorable market for Bone Morphogenetic Protein. These factors collectively contribute to the region's increasing adoption and utilization of BMP treatments.

Europe is predicted to expand substantially during the forecast period. In Europe, bone diseases like osteoporosis, osteoarthritis, and spinal disorders are increasing. The aging population, inactivity, and changing nutritional preferences all play a role in this development. This has led to a growth in interest in Bone Morphogenetic Protein (BMP) treatments and other viable regeneration options throughout Europe. Patients in the area often seek out BMP treatments because of the positive results they have seen in bone healing and tissue restoration. The frequency of bone problems is rising, and in response, several European nations have introduced helpful healthcare policies and programs. These endeavors aim to increase the use of novel therapeutics like BMP treatments.

In addition, patients can access and afford BMP treatments because of established regulatory frameworks, healthcare financing models, and reimbursement systems. As a result, European healthcare professionals are more likely to administer BMP therapies, and European patients are less likely to experience financial barriers to therapy. BMP therapies are in high demand in the area because of their potential as a regenerative solution for bone healing and tissue regeneration.

Rising healthcare spending by governments and more patient and physician knowledge of available treatment options for chronic illnesses, particularly orthopedic problems, bode well for the Asia-Pacific region's prospects over the forecast period. Regional demand for BMPs will also increase because of the expanding medical tourism business over the forecast period. In addition, patients from all over the globe seek out the Asia-Pacific area for its high-quality and low-cost medical treatments, making it a popular destination for medical tourism. Patients looking for BMP therapy may find the location appealing due to the availability of cutting-edge healthcare facilities, qualified healthcare personnel, and comparatively reduced treatment expenses.

The governments of Latin American nations are enacting policies and programs to improve healthcare delivery and encourage the adoption of cutting-edge treatments. The availability and cost of BMP therapies are being improved via the establishment of regulatory frameworks, reimbursement mechanisms, and public-private partnerships. These programs foster market expansion by encouraging healthcare professionals to administer BMP treatments. In addition, partnerships and cooperation between domestic healthcare institutions and multinational corporations are becoming more common in Latin America. BMP treatment knowledge, skills, and technology may be shared thanks to this partnership. It promotes the development of the market and the spread of BMP treatments in the area.

In the Middle East and Africa, there has been an increase in healthcare awareness and education. Healthcare providers and patients alike are being educated on the value of BMP therapy. Knowledge transmission and implementation of BMP in clinical practice are aided through medical conferences, seminars, and partnerships with foreign specialists.

Report Scope

Report Metric Details
By Type
  1. Recombinant Human Bone Morphogenetic Protein (rhBMP)-2
  2. Recombinant Human Bone Morphogenetic Protein (rhBMP)-7
By Applications
  1. Spinal Fusion
  2. Trauma
  3. Reconstructive Surgery
  4. Oral-Maxillofacial
  5. Others
Company Profiles Medtronic Stryker Corporation Merck KGaA Prospec-Tany Technogene Ltd Ember Therapeutics Thermo Fisher Scientific Akron Biotechnology LLC Sino Biological Inc Integra Lifesciences Holdings Corporation Zimmer Biomet Holdings Inc.
Geographies Covered
North America U.S. Canada
Europe U.K. Germany France Spain Italy Russia Nordic Benelux Rest of Europe
APAC China Korea Japan India Australia Taiwan South East Asia Rest of Asia-Pacific
Middle East and Africa UAE Turkey Saudi Arabia South Africa Egypt Nigeria Rest of MEA
LATAM Brazil Mexico Argentina Chile Colombia Rest of LATAM
Report Coverage Revenue Forecast, Competitive Landscape, Growth Factors, Environment & Regulatory Landscape and Trends
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Segmental Analysis

The global bone morphogenetic protein market is bifurcated into types and applications.

Based on the type, the global market is divided into rhBMP-2 and rhBMP-7.

The rhBMP-2 protein segment is the highest contributor to the market share and is expected to grow significantly over the forecast period. Recombinant Human Bone Morphogenetic Protein (rhBMP-2), a type of Bone Morphogenetic Protein, is a protein that aids in forming new bones within the body. It is commonly used in medical procedures to stimulate bone growth and facilitate healing. In addition, recombinant human bone morphogenetic protein (rhBMP-2) is made in a lab through genetic engineering. These proteins hold significant potential for various medical applications. One notable advantage of rhBMP-2 is its ability to be manufactured in large quantities, ensuring availability for clinical use. It is also considered less likely to trigger an immune response than other forms of BMPs.

Based on the application, the global market is divided into spinal fusion, trauma, reconstructive surgery, oral-maxillofacial, and others.

The spinal fusion segment owns the highest market share and is expected to grow significantly over the forecast period. Spinal fusion surgery involves using bone morphogenetic protein (BMP), which is crucial in facilitating bone formation within the body. Studies have indicated that BMP promotes fusion at a faster rate compared to traditional bone graft surgery. This attribute is particularly significant as it enables surgeons to perform the procedure more efficiently, resulting in a higher fusion success rate while avoiding the risks associated with harvesting grafts from the patient's hip (iliac crest autograft).

Additionally, the utilization of bone morphogenetic protein (BMP) in spinal fusion surgery yields several discernible advantages. The surgical procedure time is significantly reduced, leading to shorter operative durations. Using BMP also helps minimize complication rates, ultimately contributing to a smoother and less painful patient recovery process. Therefore, the growing adoption of BMP in spinal fusion surgery is driven by the increasing number of spinal operations performed and the improved surgical ease associated with BMP usage.

Market Size By Type

Market Size By Type
  • Recombinant Human Bone Morphogenetic Protein (rhBMP)-2
  • Recombinant Human Bone Morphogenetic Protein (rhBMP)-7
  • Key Players

    Bone Morphogenetic Protein Market Share of Key Players

    Bone Morphogenetic Protein Market Share of Key Players
    Medtronic Stryker Corporation Merck KGaA Prospec-Tany Technogene Ltd Ember Therapeutics Thermo Fisher Scientific Akron Biotechnology LLC Sino Biological Inc Integra Lifesciences Holdings Corporation Zimmer Biomet Holdings Inc. Others

    Frequently Asked Questions (FAQs)

    What is the projected market value of the Bone Morphogenetic Protein Market?
    The global Bone Morphogenetic Protein Market size is projected to reach USD 607.78 million by 2031.
    North America region has the highest growth rate in the Bone Morphogenetic Protein market.
    The rhBMP-2 protein market sector is expected to dominate over the forecast period.
    Medtronic, Stryker Corporation, Merck KGaA, Prospec-Tany Technogene Ltd, Ember Therapeutics, Thermo Fisher Scientific, Akron Biotechnology LLC, Sino Biological Inc, Integra Lifesciences Holdings Corporation, Zimmer Biomet Holdings, Inc. are the prominent players in the Bone Morphogenetic Protein Market.
    Rising Technological Development is one of the key trends in the Market of Bone Morphogenetic Protein.

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