Enzymatic DNA Synthesis Market Size & Outlook, 2026-2034

Enzymatic DNA Synthesis Market Overview

The global enzymatic DNA synthesis market size is valued at USD 353.04 million in 2025 and is estimated to reach USD 1,869.72 million by 2034, growing at a CAGR of 20.39% during the forecast period. The remarkable market growth is driven by the growing integration of DNA-based data storage initiatives that are uniquely boosting demand for ultra-precise enzymatic synthesis technologies worldwide.

Key Market Trends & Insights

• North America dominated the global market, accounting for 48.71% share in 2025.
• The Asia Pacific region is projected to grow at the fastest pace, with a CAGR of 22.46% during the forecast period.
• Based on service, the oligonucleotide synthesis segment held the highest market share in 2025.
• By application, the vaccine development segment is expected to register the fastest CAGR growth of 16%.
• Based on end use, the biopharmaceutical companies segment dominated the market with a revenue share of 48.07% in 2025.
• The U.S. dominates the enzymatic DNA synthesis market, valued at USD 128.53 million in 2024 and reaching USD 154.19 million in 2025.

Table: U.S. Enzymatic DNA Synthesis Market Size (USD Million)

Source: Straits Research

Market Size & Forecast

• 2025 Market Size: USD 353.04 million
• 2034 Projected Market Size: USD 1,869.72 million
• CAGR (2026-2034): 11.29%
• Dominating Region: North America
• Fastest-Growing Region: Asia Pacific

The global enzymatic DNA synthesis market comprises advanced services that enable the production of oligonucleotides and gene synthesis. These solutions support a wide range of applications, including synthetic biology, genetic engineering, vaccine development, and other emerging fields requiring rapid, accurate DNA assembly. End users such as biopharmaceutical companies, academic and research institutes, and contract research organizations rely on enzymatic synthesis to accelerate innovation and streamline molecular development workflows.

Latest Market Trends

Rising Demand for Long, High-fidelity DNA Constructs

The enzymatic DNA synthesis market is experiencing a shift driven by the rising demand for longer, high fidelity DNA constructs supporting synthetic biology and therapeutic innovation. As research moves beyond short oligos toward complex gene length sequences, chemical synthesis faces scalability and accuracy limits. This trend is accelerating the adoption of enzyme-based platforms that deliver cleaner, faster, and more precise DNA, fueling advancements in benchtop automation, enzyme engineering, and integrated synthesis to assembly workflows globally.

Breakthrough in Ultra-Long Sequence Synthesis

The increasing commercial availability of ultra-long, sequence-perfect DNA constructs is a key trend for market growth. For instance, Ansa Biotechnologies recently launched a 50 kb clonal DNA product via its proprietary enzymatic platform, delivering constructs in under 25 business days with a guaranteed on-time promise.

This innovation is reshaping synthetic biology and genomics by enabling researchers to design and build large, complex sequences that were previously impossible to synthesize.

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Market Driver

Growth in NIH-Supported Development of Benchtop DNA Printers

A key driver in the enzymatic DNA synthesis market is the accelerating shift toward benchtop, DNA printing technologies supported by substantial public investment. Growing interest in decentralized, rapid synthesis workflows is prompting innovation in compact instrumentation. For example, DNA Script received a USD 2.2 million award from the NIH’s National Human Genome Research Institute to advance development of its SYNTAX platform, designed to enable laboratories to produce high-quality, long oligonucleotides internally within a single day, enhancing efficiency and research agility.

Market Restraints

High Investment and Technical Complexity for Adoption

A notable barrier in the enzymatic DNA synthesis market is the steep cost and technical sophistication required to establish enzymatic platforms. High-end instruments, custom enzymes, and specialized automation systems demand substantial capital and expertise. For example, deploying a benchtop DNA synthesizer costs upwards of hundreds of thousands of dollars, along with ongoing reagent expenses, posing a major hurdle for small biotech startups and academic labs with limited resources.

Market Opportunity

Growing Demand for Outsourced DNA Design and Synthesis Services

A major opportunity in the enzymatic DNA synthesis market is the increasing shift toward outsourcing complex DNA construct design and production to specialized providers. Many biopharmaceutical and synthetic biology companies lack the infrastructure to generate long, high-fidelity sequences and prefer partnering with firms offering advanced enzymatic platforms. This trend enables service providers to expand capacity, deliver rapid, customizable DNA solutions, and meet the rising demand for scalable, precision synthesis required for therapeutics, vaccines, and engineered cell systems.

Regional Analysis

The North America region accounted for the highest enzymatic DNA synthesis market with a revenue share of 48.71% in 2025. This dominance is driven by the presence of innovation hubs such as Maryland’s “DNA Valley,” offering concentrated access to federal laboratories, skilled biotech talent, and commercialization support. This ecosystem accelerates development, collaboration, and adoption of advanced DNA synthesis technologies, reinforcing regional market dominance.

The U.S. market is driven by a robust venture capital ecosystem supporting synthetic biology startups. Funds such as the OS Fund actively invest in innovative enzymatic DNA companies, providing critical financial resources that accelerate research and commercialization, strengthening the country’s leadership and rapid adoption of advanced DNA synthesis technologies.

Asia Pacific Market Insights

Asia Pacific is emerging as the fastest-growing region with a CAGR of 22.46% from 2026-2034, driven by the rapid evolution of contract research and biotech manufacturing hubs in countries such as India and South Korea. These facilities offer scalable DNA synthesis services, attracting global partnerships and investments, thereby accelerating regional market adoption and supporting high CAGR growth.

The enzymatic DNA synthesis market in India is driven by the government-backed BioE3 policy, which promotes biomanufacturing and synthetic biology infrastructure. By supporting biofoundries, research hubs, and advanced DNA production facilities, the initiative enables local innovation, strengthens domestic capabilities, and attracts investments, which, in turn, support market growth.

Regional Market share (%) in 2025

Source: Straits Research

Europe Market Insights

Europe’s enzymatic DNA synthesis market is growing due to the rapid augmentation of specialized synthetic biology clusters, such as the UK’s Cambridge and Germany’s Berlin-Brandenburg hubs. These centers offer advanced infrastructure, skilled talent, and strong industry-academia collaboration, driving innovation, facilitating commercialization, and accelerating regional adoption of enzymatic DNA synthesis technologies.

The German market growth is supported by the establishment of the Carl‑Zeiss‑Stiftung Center for Synthetic Genomics in Heidelberg, KIT, and Mainz, supported with USD 13.8 million in funding. This center focuses on AI-assisted design and synthesis of long DNA sequences, enhancing regional innovation, research capabilities, and adoption of advanced enzymatic DNA technologies.

Latin America Market Insights

Latin America’s market is growing due to programs like UNU‑BIOLAC, which provide advanced training in genomics, synthetic biology, and bioinformatics across the region. By enhancing local expertise and facilitating technology transfer, these initiatives strengthen research capabilities, support innovation, and accelerate the adoption of enzymatic DNA synthesis technologies in Latin America.

Brazil’s enzymatic DNA synthesis market is strengthened by SynBioBR, the national synthetic biology network launched in 2024, which unites 32 research groups across 18 institutions to promote collaboration, drive gene engineering research, and accelerate regional adoption of advanced DNA synthesis technologies.

Middle East and Africa Market Insights

The Middle East & Africa enzymatic DNA synthesis market is uniquely boosted by the Technology Innovation Institute’s (TII) Abu Dhabi Biofoundry, launched in 2024, which provides high-throughput robotic systems, next-generation sequencing, and DNA synthesis platforms to accelerate synthetic biology research across the region.

Egypt’s market is growing due to the National Reference Genome Project, which aims to sequence 100,000 modern Egyptians and 200 ancient mummies. This large-scale initiative drives demand for advanced DNA synthesis, bioinformatics, and synthetic biology infrastructure, accelerating research capabilities and adoption of enzymatic DNA technologies nationally.

Service Insights

The oligonucleotide synthesis segment dominated the market in 2025, due to rising demand for custom primers optimized for ultra-rapid qPCR and digital PCR workflows. As diagnostic platforms increasingly rely on high specificity, short sequence primers, enzymatic synthesis offers superior accuracy and rapid turnaround, strengthening segment growth.

The gene synthesis segment is anticipated to witness growth, registering a projected CAGR of 21.43% during the forecast period. This growth is supported by increasing demand for modular, codon-optimized gene constructs tailored for strain engineering in biofoundries. As automated design-build workflows expand, enzymatic platforms enable faster assembly of customized genes, supporting high-throughput metabolic pathway optimization and accelerating segment growth.

Application Insights

The synthetic biology segment accounted for the highest market share of 36.54% in 2025, owing to growing use of cell free expression systems that require rapidly synthesized, template ready DNA fragments. Enzymatic synthesis enables faster prototyping of genetic circuits for these systems, allowing researchers to iterate designs in hours rather than weeks, boosting segment adoption.

The vaccine development segment is expected to register the fastest CAGR growth of 22.16%, owing to rising use of DNA based immunogen libraries that require precise, variant specific gene constructs. Enzymatic synthesis enables rapid generation of these customized sequences, supporting accelerated antigen screening and allowing developers to respond swiftly to emerging pathogens, driving segment growth.

By Application Share (%), 2025

Source: Straits Research

End Use Insights

The biopharmaceutical companies segment accounted for the highest market share of 48.07% in 2025. This growth is augmented by increasing investment in biologics and gene therapies, which drives high demand for reliable DNA synthesis services. Companies are expanding in house and outsourcing to accelerate R&D, boosting the segment’s market share and adoption.

The contract research organizations segment is estimated to register the fastest CAGR during 2026-2034, owing to increasing demand for customizable enzymatic DNA synthesis services. CROs enable smaller biotech and academic clients to access advanced gene and oligonucleotide production without investing in costly in-house platforms, driving segment expansion.

Competitive Landscape

The global enzymatic DNA synthesis market is moderately competitive, with a mix of established synthetic biology companies and emerging technology developers shaping the landscape. Leading players such as DNA Script, Molecular Assemblies, Ansa Biotechnologies, Evonetix, Telesis Bio, and others are advancing proprietary enzymatic platforms aimed at producing longer and faster DNA. These companies differentiate through novel enzyme engineering, benchtop DNA printers, and integrated automation, while newer entrants continue to drive innovation and broaden adoption across research, therapeutics, and industrial biotechnology.

Moligo Technologies: An Emerging Market Player

Moligo Technologies is positioning itself as a rising innovator in the enzymatic DNA synthesis market, specializing in the production of long, ultra-pure single-stranded DNA for advanced synthetic biology and genomic applications. The company utilizes proprietary enzymatic methods to deliver high-fidelity oligonucleotides optimized for gene editing and molecular diagnostics.

• In 2025, Moligo expanded its portfolio with enhanced long-read ssDNA products, gaining early adoption among biotech startups.

As a result, Moligo Technologies is steadily establishing its presence as an emerging player in the global market.

List of key players in Enzymatic DNA Synthesis Market

1. Ansa Biotechnologies, Inc.
2. Bellatrix Aerospace
3. Camena Bioscience Ltd.
4. Codexis
5. DNA Script
6. Elegen Corporation
7. Eurofins Genomics
8. Evonetix
9. GenomeWeb
10. GenScript Biotech Corp.
11. Kern Systems, Inc.
12. Molecular Assemblies, Inc.
13. Moligo Technologies
14. Synbio Technologies
15. Telesis Bio Inc.
16. Touchlight Genetics Ltd.
17. Twist Bioscience Corporation
18. Yeasen Biotechnology
19. Others

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Strategic Initiatives

• October 2025: Ansa Biotechnologies, a leading DNA synthesis company, launched the 50-kilobase (kb) Clonal DNA product, the longest sequence-perfect synthetic DNA commercially available.
• May 2025: Ribbon Bio GmbH, a DNA synthesis company, launched the MiroSynth DNA, its first commercial product designed to meet the growing demand for complex synthetic DNA molecules.