Interbody Spine Implants Market

Market Overview

The global interbody spine implants market size was valued at USD 1.89 billion in 2022. It is estimated to reach USD 2.36 billion by 2031, growing at a CAGR of 2.51% during the forecast period (2023–2031). The global market is expanding due to the rising frequency of spine problems, including degenerative disc disease, disc herniation, spinal stenosis, spondylolisthesis, and scoliosis.

Interbody spine implants are medical devices primarily used to correct spine deformities, strengthen and enhance spine stability, enable the fusion of two vertebrae, and repair spinal fractures. The primary purpose of spinal implants is to assist in the fusion of two vertebrae and to replace the natural disc material. The spine consists of bones, tendons, ligaments, spinal fluid, and spinal cords from the neck to the pelvis. The spine is a vital body structure that maintains the body upright and standing. It facilitates movement and provides the body with flexibility.

Spinal abnormalities can arise as a result of congenital defects, diseases, or trauma. The potential consequences encompass the development of lesions, the occurrence of bruising, and the occurrence of bone fractures. Interbody spine implants are a type of treatment utilized to restore the function and integrity of the biological structures of the spine. Interbody spine implants treat numerous types of back pain and spinal deformities. They also treat spinal conditions such as scoliosis, kyphosis, and degenerative disc diseases.

Market Dynamics

Global Interbody Spine Implants Market Drivers:

Rising Frequency of Strategic Acquisitions

In recent years, the spinal implants market has emerged as one of the competitive markets for M&A activities in the overall medical technology industry. The global interbody spine implants market has witnessed significant acquisitions over the last decade. Such strategic acquisitions are likely to change the market dynamics and could even shuffle the market positions of leading players during the forecast period. These strategic moves will help the acquiring organizations in the interbody spine implants market to become more consolidated globally.

For instance, in 2021, ATEC Spine acquired EOS Imaging for USD 116.9 MN. The company plans to integrate EOS technology into its AlphaInformatiX platform, adding spinal imaging and anatomical modeling. Similarly, 7D Surgical was acquired by SeaSpine Holdings in 2021 for USD 110 MN to expand and broaden the clinical value by encompassing the entire patient experience, from surgical planning to treatment and recovery.

Expanding Target Population for Interbody Spine Implants

The prevalence of spine disorders, such as degenerative disc disease, disc herniation, spinal stenosis, spondylolisthesis, and scoliosis, is increasing globally. For instance, approximately 266 million individuals are affected by degenerative spine diseases (DSDs) every year globally. Moreover, as stated by the WHO, globally, low back pain is a leading cause of economic burden on individuals and governments. In the US, around 149 million days are lost yearly due to low back pain.

The increasing prevalence of spinal disorders around the world has also led to a dramatic increase in the number of spinal surgeries. This will increase the demand for spinal devices. Spinal surgery primarily treats degenerative discs and corrections of birth deformities. In addition, the rising number of spinal fracture cases will expand the market over the forecast period. Every year, 250,000 to 500,000 people globally suffer from spinal cord injury (SCI). All these factors will contribute to the surge in spinal correction procedures and drive the demand for interbody spine implants during the forecast period.

Global Interbody Spine Implants Market Restraint:

Risks and Complications Associated with Spinal Surgeries

Spine surgeries are associated with several complications and limitations like any surgery. Complications during spine implant procedures are classified as general, specific, or technical. These are further divided into two categories, namely major and minor complications. Major complications are usually observed in 12%–30% of spine surgery cases. Minor complications are often observed in 17%-50% of spinal surgeries.

The incidence of postoperative complications exhibits variability, whereas small difficulties manifest at a rate nearly double that of significant complications. Therefore, risks and potential complications associated with spine implants used in spine implant procedures might hinder the market's growth prospects.

Global Interbody Spine Implants Market Opportunities:

Frequent New Product Launches 

In recent years, the market has witnessed the launch of several advanced and innovative spine implant devices along with major changes in product design, material use, and spinal surgery techniques. For instance, Theradaptive introduced Osteo Adapt SP used in procedures to treat degenerative disc diseases, spondylolisthesis, and retrolisthesis. Such product launches have enabled surgeons to perform spine surgeries efficiently, leading to better post-surgical outcomes.

Numerous industry participants are concentrating on creating Ti-PEEK-based advanced spinal implant solutions due to the significant demand for porous PEEK systems and surface-modified titanium spinal implants. For instance, NuVasive launched 3D printing and fully porous devices with titanium-based implants. Thus, the growing focus of vendors on technological advances and improvements has contributed to the launch of many innovative devices and a rise in demand for such devices. All these factors are expected to create opportunities for growth in the global interbody spine implants market during the forecast period.

Regional Analysis

Based on region, the global interbody spine implants market is bifurcated into North America, Europe, Asia-Pacific, Latin America, and the Middle East and Africa.

North America Dominates the Global Market

North America is the most significant global interbody spine implants market shareholder and is estimated to grow at a CAGR of 2.40% over the forecast period. The regional market is expected to sustain its dominance during the forecast period and will likely grow at a lesser CAGR than Asia-Pacific as it has matured. As a result, the region is likely to grow slower. Most of the region's growth is fueled by the growing preference for technologically advanced spine implant devices and the launch of innovative spine implants with better safety/efficacy profiles. Similarly, the market is expanding due to the relatively higher penetration of spine implants in North America than in other regions and the high volume of spinal fusion and non-fusion surgeries. For instance, in the US, the volume of elective lumbar fusion grew by approximately 62%, from about 122,679 cases in 2004 to about 199,140 in 2015.

In addition, the surge in the volume of surgeries is because of the availability of developed healthcare infrastructure, constant technological innovations, and the rise in acceptance of various SR procedures. The prevalence of various spine disorders is also increasing in the region and encouraging patients with spine disorders to undergo spine surgeries, thereby driving market growth.

Asia-Pacific is predicted to exhibit a CAGR of 3.35% over the forecast period. Some of the factors contributing to the regional market's growth include the presence of a considerably large patient population pool, improvements in healthcare infrastructure, the rise in awareness of spinal disorders and treatment options, and high healthcare expenditure. Further, the rising elderly population with a high risk of spinal disorders and higher adoption of various spine surgical procedures are expected to propel the demand for interbody spine implants in Asia-Pacific. As per the UNPFA, the aging population is expected to triple by 2050 compared to 2010 and is anticipated to reach about 1.3 billion. This region's healthcare system is also enduring a rapid transformation with the support of numerous government agencies.

In addition, healthcare providers are focused on providing advanced care to patients, thereby growing the demand for spine implants. The high healthcare expenditure increases patients' accessibility to a broad range of advanced treatment options for disc herniation and stenosis, thereby driving the demand for spine implants.

Europe accounted is growing steadily and is expected to grow at a similar rate during the forecast period. The region, particularly Western Europe, has a sophisticated and established healthcare infrastructure, and people have access to advanced healthcare services, especially for treating various spinal disorders using fusion and non-fusion procedures. The market is surging due to the rising prevalence of spine disorders and the availability of reimbursement coverage for spine surgeries in most European countries. The prevalence of spine disorders increases with age and is mainly prevalent in the 60–69 age group. The percentage of people over 50 comprises approximately 34% of the total population in Europe. This percentage is expected to increase by nearly 10% over the next 20 years. This aging population would require surgical treatment for spinal diseases, contributing to the high demand for spine implant devices.

The Middle East and African market is growing moderately and is expected to continue during the forecast period. The market is growing due to higher healthcare spending, awareness about various treatment options for spine disorders, and a large middle-class population with high spending power. Although healthcare spending in the Middle East and Africa is currently the lowest compared to other regions, the region's healthcare spending is expected to grow by around 10% annually in the coming years. Therefore, the higher healthcare expenditure and increasing awareness about surgical interventions for treating several spinal disorders will directly impact the market growth of spine implants in the region during the forecast period.

Segmental Analysis

The global interbody spine implants market is bifurcated into product type, materials, and end-users.

Based on product type, the global interbody spine implants market is segmented into lumbar and cervical interbody spine implants. 

The lumbar segment is the highest contributor to the market and is projected to exhibit a CAGR of 3.13% over the forecast period. Lumbar degenerative disease is a widespread debilitating disease that causes pain and disability in patients and costs the health care system and economy. The prevalence of back pain due to lumbar spondylosis is estimated to be 3.6% worldwide and 4.5% in North America. Back pain in 2010 lost 83% of quality-adjusted life years. As the population ages, the proportion of diagnosis and treatment of degenerative diseases of the lumbar spine increases, and the burden on the lumbar spine (both disability and cost) increases. In addition, the number of lumbar spine surgery is steadily increasing over time. The obvious benefits of lumbar fusion have been demonstrated in many patients, as evidenced by lower pain and disability scores and their ability to return to work within a shorter duration.

Cervical spine surgery is usually done selectively to treat either nerve/spinal cord collisions (decompression surgery) or spinal instability (fusion surgery). The two steps are often combined because decompression can destabilize the spine and require fusion to increase stability. Cervical spine surgery can be adapted to a variety of spinal problems. Surgery can generally be performed to correct degenerative diseases, trauma, or instability. These conditions can pressure the spinal cord or nerves coming from the spine. Goals for cervical fusion include restoration and maintenance of disc cavity height, indirect decompression of the nerve foramen, maintenance of normal lordosis, and improved stability of the affected area.

Based on materials, the global interbody spine implants market is segmented into metal, PEEK, and others. 

The metal segment owns the highest market share and is projected to exhibit a CAGR of 2.86% over the forecast period. Metals are used in the manufacturing of interbody spinal implants. The segment comprises various metals, such as titanium, stainless steel, and tantalum. The American Academy of Orthopedic Surgeons states that most spinal implants (including associated hardware) comprise titanium alloys, pure titanium, and stainless steel. Titanium and its alloys and stainless steel can be manufactured under different conditions to achieve different mechanical properties for different orthopedic applications.

Polyetheretherketone (PEEK) cages affected by autologous bone grafts have shown a high rate (92-100%) of interbody fusion, with good to excellent clinical results. Polyetheretherketone is a biocompatible polymer with a modulus of elasticity very similar to cortical bone and can result in more load distribution and better stress distribution. It withstands high temperatures and radiation, is stronger than many metals, and does not cause artifacts on MRI and CT scans. NuVasive's pioneering design to create implants for fusion adheres to the three core principles of advanced materials science-surface, structure, imaging, and combining the unique benefits of porosity with the beneficial material properties of PEEK.

Based on end-users, the global interbody spine implants market is bifurcated into hospitals, specialty orthopedic and spine centers, and ASCs. 

The hospitals segment dominates the global market and is predicted to exhibit a CAGR of 2.18% during the forecast period. This end-user segment dominates the spine implants market as most patients still prefer undergoing spine surgeries in hospitals rather than any other healthcare setting. The changing lifestyle patterns of the growing elderly population and the increasing prevalence of spinal disorders, such as low back pain, spinal stenosis, and degenerative spine disorders, are the major factors contributing to the increasing volume of spine surgeries in hospitals. For instance, about 266 million people globally suffer from degenerative spine disease (DSD) and low back pain (LBP) every year.

Specialty orthopedic and spine centers offer exclusive healthcare services to patients with suspected or diagnosed spinal diseases. These centers treat patients with various spinal deformities, such as degenerative spine disease, lumbar spinal stenosis, low back pain, disc herniation, and spinal spondylolisthesis, and offer quality care. The specialty orthopedic and spine centers end-user segment is growing at a healthier rate than the hospitals' segment. This is because of the availability of sophisticated infrastructure for diagnosing and treating spinal diseases in standalone spine care centers compared to hospitals.

Recent Developments

• May 2023- HAPPE Spine, a medical device business dedicated to introducing innovative materials to orthopedic implants, announced that the FDA had granted 510k approval for its INTEGRATE-CTM Interbody Fusion System.

• March 2023- FloSpine, a company that develops spinal fusion implants that can enhance outcomes and shorten recovery times for individuals with spine conditions, received approval from the U.S. Food and Drug Administration (FDA) for a 3D-printed implant to support the spine.