Plasmapheresis Machines Market Size, Share & Trends Analysis Report By Collection Type (Plasma Collection System, Multi-Component Collection System), By Technology (Centrifugation-Based Plasmapheresis, Membrane Filtration-Based Plasmapheresis, Others), By Application (Extracorporeal Therapy, Plasma Donation, Others), By End-User (Hospitals and Clinics, Blood Donation Centers, Research Institutes, Home Care Settings, Others) and By Region(North America, Europe, APAC, Middle East and Africa, LATAM) Forecasts, 2025-2033

Plasmapheresis Machines Market Size

The global plasmapheresis machines market size was valued at USD 1.49 billion in 2024 and is projected to grow from USD 1.60 billion in 2025 to reach USD 2.79 billion by 2033, exhibiting a CAGR of 7.8% during the forecast period (2025-2033).

Plasmapheresis machines are medical devices used to separate plasma from a patient’s blood, a process essential for plasma exchange. This procedure is often necessary for treating a range of conditions, including hematologic malignancies like leukemia, lymphoma, and myeloma. These machines not only help in the removal of harmful blood components but also play a crucial role in the management of complications, especially in patients undergoing treatments such as chemotherapy.

The increasing global incidence of hematologic malignancies is a significant driver for the market growth of plasmapheresis machines. For instance, the Leukemia & Lymphoma Society (LLS) projected that in 2023, approximately 184,720 individuals in the U.S. would be diagnosed with these conditions, representing 9.4% of the total new cancer cases. This high prevalence of hematologic cancers amplifies the demand for plasmapheresis machines, as they are vital in managing these disorders.

In addition to cancer treatment, the growing demand for plasma donations and the increasing use of plasma-derived therapies further fuel the market for plasmapheresis equipment. Technological advancements, such as the development of portable plasmapheresis devices, coupled with global awareness campaigns promoting plasma donation, are expected to contribute significantly to the market's expansion.

Plasmapheresis Machines Market Trends

Surge in regenerative medicine

The surge in regenerative medicine is a key market trend for plasmapheresis machines due to the increasing need for plasma collection. As demand for regenerative therapies such as cell and immunotherapies grows, the volume of apheresis collections rises. This requires more efficient, automated machines to handle the rising workload.

• For instance, in October 2022, as per the Association for the Advancement of Blood & Biotherapies, apheresis collections in the U.S. are projected to increase from 43,000 in 2021 to an estimated 132,000 by 2025, highlighting the growing demand driven by the surge in regenerative medicine.

Growing plasma donations and collection centers

The growing recognition of plasma's therapeutic importance is significantly impacting the plasmapheresis machines market. With increasing awareness of plasma's role in treatments like immunoglobulin therapy and hemophilia care, plasma donations are rising.

• For instance, in April 2022, Bio Products Laboratory Ltd (BPL), a leading manufacturer of plasma-derived protein therapies, opened its 29th plasma donation center.

This demand is driving the expansion of plasma collection centers and increasing the need for more efficient plasmapheresis equipment and machines.

Global Plasmapheresis Machines Market Growth Factors / Drivers

Rising incidence of chronic diseases

The increasing prevalence of chronic diseases, particularly autoimmune disorders and hematologic conditions, is significantly driving the demand for plasmapheresis. Conditions such as Guillain-Barré syndrome, chronic inflammatory demyelinating polyneuropathy (CIDP), and multiple sclerosis often require plasmapheresis to remove harmful antibodies and other detrimental substances from the bloodstream.

• For example, the World Health Organization (WHO) reported in August 2023 that over 1.8 million people worldwide are estimated to have multiple sclerosis, further highlighting the growing need for plasmapheresis as a treatment option.

Technological advancements in plasmapheresis machines

Advancements in plasmapheresis machine technology are another key factor driving market growth. Continuous improvements in machine efficiency, safety, and donor comfort are enhancing the effectiveness of plasmapheresis procedures. The introduction of automated plasmapheresis systems, along with innovations like enhanced filtration techniques, has increased plasma yield and optimized the donation process.

• For instance, in December 2022, Fresenius Kabi AG's Aurora Xi Plasmapheresis System received FDA clearance. This new system improves donor comfort and collection efficiency by utilizing automated controls, reducing manual intervention, and minimizing operator errors, leading to smoother operations and enhanced overall performance.

Market Restraining Factors

High costs of plasmapheresis machines

The high cost of plasmapheresis equipment and machines is a significant restraint on market growth. The price of a single machine can range from USD 10,000 to USD 20,000 for basic models, depending on the brand and features. High-end machines, equipped with automated functions, enhanced donor safety protocols, and real-time monitoring capabilities, can cost between USD 30,000 to USD 100,000. These substantial upfront costs pose a significant barrier, particularly for smaller or newly established plasma collection centers, limiting their ability to invest in advanced technology.

Market Opportunities

Bridging the skilled workforce gap

The shortage of skilled professionals in the healthcare industry is a critical restraint impacting the plasmapheresis machines market, as these advanced systems require specialized expertise for proper operation and maintenance. According to the World Health Organization 2024, there is an estimated global shortfall of 10 million healthcare workers by 2030, particularly in low- and middle-income countries.

This shortage, however, presents a significant opportunity for companies to invest in specialized training programs. By collaborating with healthcare institutions, governments, and educational organizations, companies can develop certified programs to train healthcare workers in the operation and maintenance of such machines.

This strategy helps meet the growing demand for skilled personnel, improves the safety and efficiency of plasmapheresis procedures, and positions companies as leaders in addressing workforce development challenges in the healthcare sector.

Regional Insights

North America: Dominant region with 42.5% market share

North America holds the largest market revenue in the global plasmapheresis machines market due to several factors. The increasing prevalence of conditions such as sickle cell disease (SCD) in the U.S., which often requires lifelong blood transfusions, drives demand for plasmapheresis equipment to efficiently provide plasma.

• For instance, in May 2024, the CDC reported that SCD affects around 100,000 people in the U.S., with over 90% being non-Hispanic Black or African American.

Moreover, the growing awareness of plasma donation's impact on patient care, along with rising plasma transfusion needs in healthcare facilities, led to an increase in plasma donors.

Asia Pacific: Fastest growing region with the highest market CAGR

The Asia-Pacific region is projected to experience the fastest growth rate in the global plasmapheresis machines market, driven by several key factors. The increasing prevalence of chronic diseases, such as autoimmune disorders and immunodeficiencies, is significantly fueling the demand for plasma-based therapies. As these conditions require plasmapheresis as part of their treatment regimen, the need for advanced plasmapheresis machines continues to rise across the region.

Moreover, the rise of medical tourism in countries like India and Thailand is accelerating demand for plasmapheresis machines. These countries are becoming popular destinations for international patients seeking affordable plasma-based treatments, further increasing the need for state-of-the-art plasmapheresis technology. This combination of factors positions the Asia-Pacific region for rapid expansion in the plasmapheresis machines market.

Country Insights

The plasmapheresis machines market is witnessing growth globally, with certain key countries making significant contributions due to their healthcare infrastructure, rising demand for plasma-based therapies, and increasing plasma donation campaigns. Developed countries like the United States, Germany, and Japan lead the market due to their advanced healthcare systems, high prevalence of autoimmune diseases, and strong plasma collection infrastructure.

Below is the analysis of key countries impacting the market:

• U.S.: According to the Red Cross Blood Donation, in January 2024, there was a continuous demand for plasma, with approximately 6,500 units of plasma needed daily. This high plasma demand drives the need for advanced plasmapheresis machines as these machines are essential for efficiently collecting plasma to meet the needs of critical treatments, such as immunoglobulin therapy and transfusions for conditions like sickle cell disease.
• Canada: In September 2022, Canadian Blood Services (CBS) partnered with Grifols SA to strengthen Canada’s national plasma supply, a move that directly impacts the plasmapheresis machines market. This partnership increases the need for advanced machines to support the expanded plasma collection efforts, ensuring efficient and high-volume plasma extraction.As the demand for plasma-derived therapies continues to rise, such collaborations are expected to drive further growth in the market by enhancing plasma collection infrastructure and capacity.
• Japan: In May 2023, as per ScienceDirect, the rising prevalence of multiple sclerosis (MS) in northern Japan increased from 18.5 per 100,000 in 2016 to 23.3 in 2021. As MS cases continue to grow, the need for plasmapheresis machines to support treatment in both hospitals and specialized centers is expected to increase, further boosting the market.
• India: According to the Frontiers, in December 2023, India accounted for 14.5% of global sickle cell disease (SCD) newborns, with an estimated 42,000 cases annually. This drives demand for plasmapheresis machines to support life-saving plasma exchange treatments for managing severe SCD complications.
• China: In December 2024, according to Frontier’s estimation, 2.7–3.0% of the adult Chinese population, which is approximately 31 million population, have one or more autoimmune diseases, with the majority of cases stemming from autoimmune diseases and rheumatoid arthritis, driving the market growth.
• UK: As per Versus Arthritis 2024, a significant number of individuals in the UK are diagnosed with Rheumatoid Arthritis, estimated at 450,000, and Psoriatic Arthritis, at 190,000, driving the demand for plasmapheresis machines. Both conditions can lead to severe autoimmune responses where plasmapheresis is used to remove harmful antibodies from the blood, providing relief in cases unresponsive to traditional therapies.
• Germany: In October 2023, the German Red Cross hosted a blood donation campaign at the UMFST-UMCH Campus in Hamburg-Bahrenfeld. This initiative is part of the ongoing efforts to meet the rising demand for blood and plasma donations in Germany. With increased plasma collection efforts, such campaigns are expected to drive the demand for plasmapheresis machines, as they play a vital role in efficiently separating and collecting plasma for life-saving treatments.

Segmentation Analysis

The global plasmapheresis machines market is segmented into collection type, technology, application, and end-user.

By Collection Type

The plasma collection system holds the largest market share due to its critical role in blood donation centers. These systems are specialized for efficiently due to their critical role in blood donation centers, efficiently extracting plasma for therapies like immunoglobulins and clotting factors. Rising global demand for these products, especially for treating immune deficiencies and hemophilia, has made these systems essential.

Plasma collection systems are designed for high throughput and continuous operation, making them indispensable in large-scale donation settings. Their robustness, ease of use, and ability to handle large donor volumes further cement their dominance in the market, aligning perfectly with the operational needs of blood banks and plasma centers worldwide.

By Technology

The centrifugation-based plasmapheresis segment dominates the global market. This method utilizes centrifugal force to efficiently and rapidly separate plasma from blood cells, making it highly effective in high-volume and time-sensitive environments such as blood donation centers and hospitals. Its ability to handle large volumes of blood and achieve reliable plasma separation in a short period makes it the preferred technology for both therapeutic and donation purposes.

Centrifugation's well-established technology, coupled with its proven track record for speed, precision, and reliability, ensures its continued dominance in the market. The method is particularly favored in settings where time is critical and the need for accurate, rapid processing is paramount. This combination of efficiency and consistency positions centrifugation-based plasmapheresis as the technology of choice, maintaining its leadership over emerging alternatives.

By Application

The plasma donation segment holds the largest market share in the global market. This dominance is driven by the global push to increase plasma donations by launching campaigns and expanding plasma collection infrastructure.

• For instance, in July 2021, NHS Blood and Transplant (NHSBT) launched its first plasma donation campaign aimed at recruiting donors for plasma-based medicines.

Moreover, advances in plasmapheresis technology, which enhance donor comfort and efficiency, further strengthen this segment's growth, highlighting the critical role of plasma in healthcare and the expanding plasma products market.

By End-User

The hospitals and clinics segment dominates the market, holding the largest market revenue primarily due to their crucial role in delivering therapeutic plasmapheresis treatments. These facilities are well-equipped to manage a wide range of procedures for conditions such as autoimmune diseases, neurological disorders, and blood disorders. The presence of skilled healthcare professionals and advanced medical infrastructure further supports the extensive use of plasmapheresis technology in these settings.

Impact of covid-19

COVID-19 had prompted the World Health Organization to proclaim a worldwide pandemic for public health emergency in March 2020. The pandemic began in December 2019 in Wuhan, China, and quickly escalated from a localized catastrophe to a global pandemic. Several well-known biopharmaceutical and pharmaceutical companies, small businesses, and startups have developed effective therapies for coronavirus infection. 

Currently, no particular medications for their therapy have been authorized. On the other hand, convalescent plasma (CP) treatment has been shown to improve the survival rate of COVID-19 infected patients based on favorable results from various clinical trials. As a result, federal authorities in nations such as the United States and India are coming forward to provide plasma treatment to patients as quickly as feasible while conducting clinical trials to assess the safety and effectiveness of this therapy. For example,

• In May 2020, the National Agency for Medicines and Health Product Safety (ANSM) in France ruled that immune plasma therapy could be used to treat severely sick COVID-19 patients.
• In April 2020, the Indian Council for Medical Research (ICMR) approved establishing a protocol for convalescent plasma therapy trials to treat highly sick COVID-19 patients at the Sree Chitra Tirunal Institute for Medical Sciences and Technology (SCTIMST India).

Company Market Share

The plasmapheresis machines market is characterized by a highly fragmented landscape, featuring numerous local and regional players alongside established industry leaders. Key players, including Baxter International Inc., Charles River Laboratories Inc., and Fresenius Medical Care, are at the forefront of innovation, continually expanding their service portfolios to meet increasing demand.

These companies drive advancements in technology and operational efficiency, while other firms contribute significantly by providing specialized services and cutting-edge solutions. This diverse competitive environment underscores the rapid market growth and dynamic evolution of the market, where ongoing innovation and service diversification are critical for success.

Asahi Kasei: An emerging player

Asahi Kasei is considered an emerging company in the plasmapheresis market due to its research and development, particularly in blood processing technologies. Their advancements in automation and efficiency enhance the donor experience and operational effectiveness of plasma collection centers. The company is actively working on innovations to improve the efficiency and safety of plasma separation, positioning itself to meet increasing industry demands for high-quality plasma collection systems.

Recent developments at Asahi Kasei include:

• In November 2023, Asahi Kasei Medical expanded its footprint in the biopharmaceutical sector by inaugurating a new Bioprocess Technical Center in Suzhou, Jiangsu Province, China. This strategic expansion reinforces Asahi Kasei’s commitment to improving operational efficiency in the growing plasmapheresis machine market, positioning the company to better serve the increasing demand for plasma-derived therapies and innovative solutions in the region.

  Analyst Opinion

  According to our analyst, the global plasmapheresis machines market presents significant growth opportunities. The growing prevalence of autoimmune diseases, hematologic malignancies, and neurological disorders is driving the demand for plasma-derived therapies, making plasmapheresis a critical component of modern healthcare.

  Moreover, the rise in global plasma donation campaigns and the increasing reliance on plasma for life-saving treatments are creating a sustained need for advanced, efficient plasmapheresis equipment and machines. Companies entering this space can expect strong growth opportunities, particularly by targeting plasma collection centers and hospitals in both developed and emerging markets.

  However, a focus on innovation, regulatory compliance, and building partnerships with healthcare providers will be crucial for long-term success.