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Protein Labeling Market

Protein Labeling Market: Information by Product (Reagents, Kits, and Services), Applications (Cell-based Assays, Fluorescence Microscopy), and Region — Forecast till 2030

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Market Snapshot

market snapshot
Base Year:
Study Period:
8.55 %
Fastest Growing Market:
Largest Market:
North America

The global protein labeling market was valued at USD 1.98 billion in 2021. It is projected to reach USD 4.14 billion by 2030, growing at a CAGR of 8.55% during the forecast period (2022–2030). Proteins are the biggest and most significant biomolecules in a living thing because they are crucial for its functioning. In a cell, proteins are created and interact with other biomolecules to perform functions that keep the cell alive. Therefore, studying the protein binding mechanism is critical in specialized fields like proteomics and protein chemistry. Most of these techniques focus on the capacity to selectively visualize, manipulate, and entrap proteins in demanding biochemical environments by genetically fusion tagging in a particular way. Several methods are used to label proteins effectively.

The research of post-translational modification (PTM) of proteins has gained enormous popularity in cell biology and in treating and averting disease. An experimental determination of PTMs has been facilitated by developing efficient methods for quantifying protein expression through tagging techniques, such as the iodoTMTzero Label Reagent that detects nitrosylation. The introduction of improved products and the development of novel techniques are anticipated to impact the market expansion positively.

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Market Dynamics

Global Protein Labeling Market Drivers

Growing Investments in Research and Development

The discovery of biomarkers that can identify the presence of a disease or the gene/protein that causes it has been aided by increased funding for life sciences research, enabling molecular studies to learn more about the fundamental mechanisms by which diseases develop. As a result, increased investments in proteomics and genomics research and development drive the market. Applications for protein labeling are frequently used for a variety of purposes.

Rising Utilization of Bioengineering Technologies

One of the critical elements positively affecting the demand for protein labeling in the healthcare sector is the expanding use of bioengineering technologies. Protein labeling is frequently used to detect protein modifications and isoforms in multiplexed samples, streamline detection workflows, and accurately quantify compounds. Additionally, researchers from all over the world are focusing on improving the accuracy, resolution, and procedures of protein labeling techniques to serve as a replacement for fluorescent proteins. These methods are also employed to investigate how proteins are localized and function in living and fixed cells.

Global Protein Labeling Market Restraint

Drawbacks Related to Protein Labeling Techniques

The market is anticipated to be restricted by the drawbacks of protein labeling techniques, such as the complexity and flexibility of the wet lab and the fact that labeled techniques are less preferred than label-free techniques. While measuring label-free samples only requires a minimal setup, wet lab pre-treatment is necessary for all labeling techniques. Chemical or metabolic reagents must be used to label the samples. Therefore, wet lab errors are less likely to occur using label-free methods than labeling methods. Therefore, it is anticipated that disadvantages associated with protein labeling techniques will hinder the market.


Segmental Analysis of the Global Protein Labeling Market

The global protein labeling market is segmented into product, application, and method.

Based on product, the market is categorized into reagents, kits, and services.

The reagents sector is the market leader and source of significant global revenue. The segment is anticipated to grow due to an increase in the discovery of labeling agents and genetically engineered labels. Additionally, the market's expansion is influenced favorably by the commercial availability of effective reagents like No-Stain Protein Labeling Reagent, which enables precise and trustworthy protein visualization and normalization. The protein sub-segment will dominate the market regarding revenue share in the reagent segment. The cause of this is due to the use of monomeric fluorescent proteins, which address issues with aggregation caused by electrostatic or hydrophobic interactions between the host and fluorescent protein.

Based on application, the market is divided into cell-based assays, fluorescence microscopy, immunological techniques, protein microarray and mass spectrometry.

The market leader and source of the largest revenue share is the immunological techniques sector. Most immunological techniques use labels, including immunoassays, western blotting, flow cytometry, and immunofluorescence. These methods are primarily employed in the study of cancer, autoimmune diseases, and the creation of therapeutics. Furthermore, these methods are widely used in detecting gastrointestinal, pulmonary, neurological, rheumatoid, and lupus diseases, as well as diabetes and systemic lupus erythematosus.

Based on the method, the market is bifurcated into in-vitro labeling methods and in-vivo labeling methods.

The in-vitro method segment has the largest revenue share and is expected to grow at a promising CAGR during the forecast period. Due to the particular action of the enzymes, enzymatic labeling has the largest market share. An enzyme's covalent site-specific binding helps proteins incorporate bio-orthogonal functionalities, enabling site-specific protein engineering and labeling. In-vitro techniques using nanoparticles are anticipated to have the fastest CAGR during the forecast period.


Regional Analysis of the Global Protein Labeling Market

The global protein labeling market is segmented into four regions, namely North America, Europe, Asia-Pacific, and LAMEA.

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North America dominates the global protein labeling market. This region now accounts for a more significant portion of global research expenditure gratitude to the increased use of cell-based assays, ELISA, western blotting, fluorescence microscopy, and immunological techniques. The widespread use of protein labeling methods in disease diagnosis research will further boost the region's dominance. Due to ongoing research projects, the market is expected to grow fastest in the Asia-Pacific region.


Competitive Analysis of the Global Protein Labeling Market

  • Thermo Fisher Scientific, Inc.
  • Merck KGaA
  • Perkin Elmer, Inc.
  • Promega Corp.
  • F. Hoffmann-La Roche Ltd.
  • LGC Ltd.
  • New England Biolabs
  • LI-COR, Inc.
  • GE Healthcare
  • Jena Bioscience GmbH


Recent Developments

  • June 2022- Merck Announces Collaboration with Agilent Technologies to Fill Industry Gap in Process Analytical Technologies for Downstream Processing. Merck, a leading science and technology company, announced that it had collaborated with Agilent Technologies to advance Process Analytical Technologies (PAT). PAT, strongly encouraged by global regulatory authorities, is a crucial enabler for real-time release and Bioprocessing 4.0.
  • March 2022- Promega Corporation and FUJIFILM Cellular Dynamics Announced Strategic Collaboration to Advance Novel Assay Development. Promega Corporation (Promega), a leader in providing innovative solutions and technical support to the life sciences industry, and FUJIFILM Cellular Dynamics, Inc., a leading global developer, and manufacturer of human induced pluripotent stem cell (iPSC) technologies, announced a strategic collaboration to advance novel assay development for drug discovery.


Global Protein Labeling Market: Segmentation

By Product 

  • Reagents
    • Kits
    • Services

By Applications

  • Cell-based Assays
  • Fluorescence Microscopy
  • Immunological Techniques
  • Protein Microarray
  • Mass Spectrometry

By Methods

  • In-Vitro Labeling Methods
  • In-Vivo Labeling Methods

By Regions

  • North America
  • Europe
  • Asia-Pacific
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