Protein Purification and Isolation Market Size & Outlook, 2022-2030

Market Overview

The global protein purification and isolation market size was valued at USD 7.28 billion in 2021. It is projected to reach USD 19.02 billion by 2030, growing at a CAGR of 11.26% during the forecast period (2022–2030).

Protein purification is the separation of proteins from complex mixtures of cells, tissues, or organisms based on the differences in their physical properties. The protein purification process aims to isolate a large quantity of functional protein with minimal impurities.

The process separates proteins from non-protein components in a mixture to obtain the desired protein. Rapid purification kits are utilized to reduce the time required for purification and isolation without sacrificing efficiency. Affinity tags are commonly used for protein isolation and purification because they allow for one-step purification. ProteoSpin Inclusion Body Protein Isolation Micro and Maxi Kits are used to rapidly isolate body proteins in 60 minutes. Protein purification and separation technologies are utilized effectively in various applications, including drug screening, affinity chromatography, gel electrophoresis, biomarker discovery, protein therapeutics, and target identification.

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Market Dynamics

Global Protein Purification and Isolation Market Drivers

Rising Investments by Governments

The pharmaceutical and biotechnology markets benefit from increased government spending on research and development (R&D) and initiatives supporting their development and expansion. They also provide additional advantages in tax breaks, grants, and regulations. The pharmaceutical industry is a highly lucrative market for products involving protein purification and isolation due to the significant investments made in researching and developing molecules specific to biomarkers.

Rising Demand for Rapid Purification Kits

The rising demand for rapid purification kits to rapidly screen, prepare, purify, and concentrate protein samples is driving the global protein purification and isolation market. In addition, various factors, such as increased funding from public and private research organizations for R&D and expanding research in structure-based drug design, contribute to the market's expansion.

Global Protein Purification and Isolation Market Restraint

High Initial and Maintenance Cost

The accurate separation of proteins using a sizeable quantity of purified substrate is an essential step in the preclinical stage of the drug development process. The global market for the purification and isolation of proteins is likely to expand due to these factors. The high cost of tools, the difficulty of maintaining purification kits that fit all proposes, and instruments that result in a lower acceptance rate impede market expansion.

Regional Analysis

The global protein purification and isolation market is segmented into four regions, namely North America, Europe, Asia-Pacific, and LAMEA.

North America is the most extensive shareholder in the global protein purification and isolation market. The rise in biopharmaceutical drug development is anticipated to propel the regional market during the forecast period. The Asia-Pacific region is projected to experience the highest growth rate during the forecast period. The demand for protein purification and isolation solutions in this region is anticipated to be driven by initiatives undertaken by the governments of developing nations, such as India and China. In addition, these governments provide funding for the creation of innovative purification and isolation techniques.

Segmental Analysis

The global protein purification and isolation market is segmented by product, technology, application, and end-user.

Based on product, the market is bifurcated into instruments and consumables.

The consumables segment is dominant in the global protein purification and isolation market. The most frequently used consumables are columns, reagents, kits, resins, and magnetic beads. Kits dominate the consumables market because they are practical and have many advantages. The advanced resins market has grown due to widespread application and increased commercialization. Furthermore, reagents ensure accurate results and help eliminate the uncertainty. The instruments segment is anticipated to expand steadily due to the development of precise, delicate, and portable instruments.

Based on technology, the market is categorized into ultrafiltration, precipitation, chromatography, electrophoresis, western blotting, and others.

The chromatography segment is the largest revenue holder and is expected to experience significant growth during the forecast period. Chromatography is one of the most precise and sensitive methods for separating and purifying proteins. As a result, many businesses are concentrating on commercializing fresh goods built on this technology to diversify their product lines.

Based on end-user, the market is divided into drug screening, biomarker discovery, protein-protein interaction studies, and diagnostics.

Protein-protein interaction studies have dominated the market and are anticipated to experience substantial growth during the forecast period. High adoption of these techniques for deriving highly purified proteins and an increasing number of structural protein-based studies contribute to the expansion of this market segment. The drug screening segment is anticipated to experience the highest growth rate during the forecast period. It is widely utilized for the discovery of innovative drugs with various applications. Drug screening involves the development of drugs with greater efficacy and fewer side effects than conventional drugs.

List of key players in Protein Purification and Isolation Market

1. Merck KGaA
2. Thermo Fischer Scientific, Inc.
3. G.E. Healthcare Life Sciences
4. Qiagen N.V.
5. Sigma Aldrich Corporation
6. Agilent Technologies
7. Bio Rad Laboratories, Inc.
8. Promega Corporation
9. Abcam
10. Norgen Biotek Corporation

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Recent Developments

• June 2022- Merck and Mulliken Center for Theoretical Chemistry Collaborated in Machine Learning Project. The three-year collaboration will focus on developing new tools for computational chemistry modeling and new molecular representations.
• May 2022- QIAGEN acquired a majority stake in enzymes provider BLIRT S.A. QIAGEN N.V. (NYSE: QGEN; Frankfurt Prime Standard: QIA) announced that it has signed agreements to acquire a 96% majority ownership stake in BLIRT S.A. (Polish Stock Exchange: BLR), a manufacturer of recombinant enzymes for the life science industry based in Gdansk, Poland.
• April 2022- Thermo Fisher Scientific Enhanced Clinical Research Solutions in Collaboration with Matrix Clinical Trials. The PPD clinical research business of Thermo Fisher Scientific Inc., the world leader in serving science, and Matrix Clinical Trials, a Matrix Medical Network offering, collaborated to bring clinical trials to patients with an innovative decentralized clinical trial (DCT) solution.