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Bovine-Based Collagen for Biomedical Applications Market

Bovine-Based Collagen for Biomedical Applications Market: Information by Application (Bone Graft Substitutes, Collagen-based Scaffolds, Hemostats), and Region—Forecast Till 2031

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Market Overview

The global bovine-based collagen for biomedical applications market size was valued at USD 991.90 million in 2022. It is projected to reach USD 2,263.41 million by 2031, growing at a CAGR of 9.60% during the forecast period (2023-2031). 

The rising prevalence of disorders and diseases, the increasing use of bovine-based collagen products in dental and orthopedic surgeries, and ongoing research and development are some major factors driving the market's growth. Other key factors include the growing demand for bovine-based collagen products to treat various diseases and disorders, including skin regeneration, bone defects, sarcopenia, wound healing, dental therapy, gastroesophageal reflux, osteoarthritis, and rheumatoid arthritis. However, the market's growth is anticipated to be constrained by the risk of disease transmission associated with products derived from bovines.

Market Snapshot

market snapshot
Base Year
: 2022
Study Period
: 2021-2031
: 9.60 %
Fastest Growing Market
: Europe
Largest Market
: North America
Market Size
: USD 2,263.41 million by 2031
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Market Dynamics

Global Bovine-based Collagen for Biomedical Applications Industry Drivers

Bovine-Based Collagen is in High Demand to Treat a Variety of Diseases

It has long been known that collagen products are suitable for human health, especially for the elderly. Clinical research on skin regeneration, bone defects, sarcopenia, wound healing, dental therapy, gastroesophageal reflux, osteoarthritis, and rheumatoid arthritis has examined collagen therapy's effects. In clinical studies, collagen therapies have a considerable impact, according to a paper titled "A Review of the Effects of Collagen Treatment in Clinical Studies," published by Multidisciplinary Digital Publishing Institute in November 2021. The comorbidity of the illnesses mentioned above, especially COVID-19, in a patient may be related to collagen deficiency, and collagen therapy may be an appropriate alternative. 

Collagen helps in the treatment of acute and chronic wounds like cuts, burns, and ulcers linked to other illnesses by stimulating natural development and assisting in the debridement of contaminated tissues, according to the study titled "Bovine Based Collagen Dressings in Wound Care Management" published in the "Journal of Pharmaceutical Research International" in December 2020. To lessen unfavorable outcomes, including infection, pain, and other negative impacts, the usage of collagen biomaterials obtained from cows is growing in popularity. Bovine-based collagen is anticipated to be more widely used in treating acute and chronic wounds due to its applications in expanding markets, including acute and chronic wound care, which will further propel market expansion.

Global Bovine-based Collagen for Biomedical Applications Market Restraint

High Risk of Transmission of Disease

Bovine spongiform encephalopathy (BSE), generally known as mad cow disease, is an infectious, fatal condition that affects adult cattle's central nervous system. The U.S. Department of Agriculture has examined hundreds of thousands of cattle for BSE (USDA). A prion protein, typically present on cell surfaces, is assumed to be the infectious agent that causes mad cow disease. The brain and spinal cord are among the nervous system tissues killed by this protein when it is changed. The growth of the market under study is anticipated to be hampered by issues, including the potential risk of bovine spongiform encephalopathy (BSE) connected with collagen derived from cows.

Global Bovine-based Collagen for Biomedical Applications Industry Opportunities

Demand for Dental and Orthopedic Surgeries is Rising

This market is anticipated to increase due to factors such as the rising incidence of orthopedic and dental conditions and the rising need for bovine collagen to treat those conditions. The prevalence of dental healthcare needs across all types of dental care was 49%, according to a study titled "What is the global prevalence of dental healthcare demands and unmet dental needs among adolescents?" published in the journal "Evidence-Based Dentistry" in March 2021. The prevalence of needs for periodontal therapy was highest (71%), followed by demands for general treatment (59%), needs for orthodontic treatment (46%), and needs for malocclusion treatment (39%). 

The increasing use of collagen from cows in dental operations is another factor anticipated to fuel market expansion. For instance, peri-implantitis is one of the most frequent biological side effects of dental implants, according to a study named "Nonsurgical Treatment of Peri-Implantitis: Case Series" published in "Multidisciplinary Digital Publishing Institute" in July 2020. In addition to local antibiotics (doxycycline, lincomycin, and erythromycin), mechanical and chemical cleaning of the dental implant surface, and a minimally invasive regeneration method with injections of bovine collagen, there are several nonsurgical ways to treat peri-implantitis. 

Segmental Analysis

The global bovine-based collagen for biomedical applications market is segmented by application.

Based on application, the global bovine-based collagen for biomedical applications market is bifurcated into bone graft substitutes, collagen-based scaffolds, hemostats, skin substitutes, cartilage repairs, and other applications.

The bone graft substitutes segment is the highest contributor to the market and is estimated to boost at a CAGR of 10.40% during the forecast period. Bone grafts are materials for implanting that promote bone formation, bone healing, and osseous restoration due to their osteoconductive, osteogenic, and osteoinductive properties. Calcium phosphate and calcium sulfate replacements are frequently utilized in place of bone graphs. A bone substitute is a synthetic, inorganic, or biologically organic mixture that can be used in place of autogenous or allogenous bone to treat a bone deficiency. Collagen and hydroxyapatite with a carbonate substitution make up the majority of bone. Such components are likely to provide an implant that performs better. Collagen's ductile qualities contribute to the improvement of hydroxyapatites' poor fracture toughness. As a result, bone graft alternatives are frequently employed in orthopedic procedures for various purposes.

The engineering of several tissues, including cartilage, bone, tendon, ligament, skin, blood vessels, and teeth, is frequently done using scaffolds made of collagen. Collagen in stands is routinely functionalized with a range of ligands and factors, including stem cells, embryonic, or human cells, to improve its binding specificity and activity. Numerous advantages of collagen derived from cows include the prevention of bone loss, the improvement of skin health, and the alleviation of arthritis. Osteochondral scaffolds made of type-I collagen enhance bone and cartilage repair. These collagen-based scaffolds are also utilized in reconstructive surgery as skin or intestine to seal wounds. Vascular tissue engineering uses the decellularized cow aorta as a 3D elastin scaffold.

To maintain blood inside a broken blood vessel, the process of hemostasis both stops and prevents bleeding (the opposite of hemostasis is hemorrhage). It is the initial phase of wound recovery. Coagulation, or the transformation of blood from a liquid to a gel, is involved. Hemostasis products increase patient care in general and the outcomes of hemostasis procedures. Avitene Microfibrillar Collagen Hemostat (MCH), an absorbable hemostat made of bovine collagen, is widely used as an adjuvant to hemostasis worldwide. The Avenue Microfibrillar Collagen Hemostat (MCH) has been demonstrated to achieve hemostasis with favorable patient outcomes and a safe profile in various applications, including orthopedic, splenic, hepatic, oral, and otolaryngologic surgery, among others. This is according to an article published in the National Library of Medicine 2021.

The simplest of the tissue-engineered organ constructs, skin substitutes, have been created over many years for testing medicines and commercial items and as models for skin biology and pathology. They are based on the spontaneous formation of a skin-like structure by fibroblasts and keratinocytes. Still, they have been expanded by adding other cell types to provide models of the diverse characteristics of intact skin. A diverse range of biosynthetic materials known as skin replacements can cover open skin wounds permanently or temporarily. Collagen made from cows is frequently utilized in skin replacements. Skin replacements made of bovine collagen are thought to be effective therapies for wound healing because they mimic the skin's natural structure. 

The area where bones and joints meet is cushioned and covered by cartilage, a white-polished substance. It serves as a shock absorber and lubricant for moving parts. Damage to the cartilage may appear as a crater or hole on the joint's smooth outer surface. The joint may become stiff, swollen, and uncomfortable if it is not addressed. It may even progress to the point where a total joint replacement with metal and plastic components is necessary. By directing the body's cells to generate new cartilage or replace destroyed cartilage, the process of cartilage repair/regeneration seeks to restore damaged cartilage. Bovine collagen-based scaffolds, often utilized in cartilage repair, are created to resemble and regenerate native tissues. Hyaline cartilage regeneration can be facilitated by tailoring these collagen-based scaffolds' pore structure and breakdown rate.

Tendon repair, cardiology, general, and aesthetic operations (dermal fillers, suture line reinforcement), among others, are some of the other uses for bovine-based collagen. Surgery to repair a torn or damaged tendon is known as a tendon repair. These are the supple tissues that resemble bands and attach muscles to bones. The National Institutes of Health study published in 2021 claims that a bovine collagen matrix can prevent tendon adhesion. Additionally, 10,129,528 cosmetic surgical procedures were carried out in 2020, according to the Global Survey Results 2020 report issued by the International Society of Aesthetic Plastic Surgery (ISAPS). The demand for other market sectors is increasing due to the increase in cosmetic surgery procedures.

Regional Analysis

The global bovine-based collagen for biomedical applications industry is bifurcated into four regions: North America, Europe, Asia-Pacific, and LAMEA. 

North America Dominates the Global Market

North America is the major revenue contributor and is expected to boost at a CAGR of 8.95% during the forecast period. The increasing need for bovine-based collagen to cure various ailments, the adoption of strategic efforts by market players, and the rise in orthopedic problems in the United States are the main drivers of market expansion. For instance, the market is expanding in the United States due to satisfying outcomes in treating osteoarthritis (OA). One of the most frequent chronic diseases and causes of disability is osteoarthritis (OA). Osteoarthritis (OA), the most prevalent kind of arthritis and a significant chronic condition affecting 1 in 7 adults in the United States, affected 32.5 million people in 2020, according to the National Public Health Agenda for Osteoarthritis 2020 Update by the Osteoarthritis Action Alliance.

Europe is expected to grow at a CAGR of 9.80% during the forecast period. Due to essential factors like the execution of strategic efforts by market participants and the rising need for bovine-based collagen to treat orthopedic ailments, the market in Germany is predicted to expand. For instance, according to a November 2021 article titled "Risk of psoriatic arthritis depending on age: analysis of data from 65 million people on statutory insurance in Germany," both the age- and sex-specific incidence of psoriatic arthritis (PsA) showed a steady rise with increasing age until it reached a peak just before the age of 60 and then began to decline. Women had a more excellent maximum value than men (40 per 100,000 py) (30 per 100,000 py). Additionally, the incidence rate tends to increase during the survey.

In China, the market for bovine-based collagen used in biomedical applications is anticipated to expand due to expanding orthopedic and dental operations, increased regenerative medicine research and development activities, and increased product launches. Due to factors like the aging population and rising incidence of osteoarthritis, more knee and hip replacement surgeries are anticipated in China during the projection period. For instance, the prevalence of symptomatic knee osteoarthritis in China as a whole was 14.6%, according to a study titled "The Prevalence of Symptomatic Knee Osteoarthritis concerning Age, Sex, Area, Region, and Body Mass Index in China: A Systematic Review and Meta-Analysis" that was published in July 2020. Products made from cows are used to treat osteoarthritis pain and other ailments, which raises consumer demand and propels the market.

Brazil, Argentina, Chile, Bolivia, Colombia, Ecuador, Paraguay, Peru, South Africa, Saudi Arabia, Kuwait, Bahrain, Qatar, the United Arab Emirates, Oman, Israel, Egypt, Iran, Syria, Jordan, and Lebanon are all included in the rest of the world category. The rising need for bovine-based collagen to treat various diseases, the increasing demand for dentistry and orthopedic procedures, and the ongoing R&D for developing wound-healing and regenerative therapies are key factors influencing the market's growth. The Central Agency for Public Mobilization and Statistics in Egypt estimates that the number of road accidents reported in the first half of 2019 increased by about 17.9% compared to the same period last year. According to the National Center for Statistics and Information, 2,210 accidents occurred in Oman in 2019. 

Bovine-Based Collagen for Biomedical Applications Market Regional Analysis
Regional Growth Insights Download Free Sample

Top Key Players of Bovine-Based Collagen for Biomedical Applications Market

The global bovine-based collagen for biomedical applications market’s major key players are

  1. Symatese
  2. Darling Ingredients Inc. (Rousselot)
  3. Foodmate Co. Ltd
  4. Botiss Biomaterials GmbH
  5. Medtronic PLC
  6. Kyeron
  7. Collagen Matrix Inc.
  8. Collagen Solutions PLC
  9. Titan Biotech

Report Scope

Report Metric Details
CAGR 9.60%
Forecast Period 2023-2031
Report Coverage Revenue Forecast, Competitive Landscape, Growth Factors, Environment & Regulatory Landscape and Trends
Segments Covered
  1. By Applications
    1. Bone Graft Substitutes
    2. Collagen-based Scaffolds
    3. Hemostats
    4. Skin Substitutes
    5. Cartilage Repairs
    6. Other Applications
Geographies Covered
  • North America
  • Europe
  • APAC
  • Middle East and Africa

Recent Developments

  • August 2022- The Roots Brands introduced an anti-aging supplement made of hydrolyzed bovine collagen and entire colostrum powder. GMBMY claims to help increase skin moisture, enhance suppleness and decrease wrinkles by utilizing bovine collagen's ability to stimulate the formation of types I and III collagen in people.
  • March 2022- Aleph Farms said that it was bringing a unique platform for manufacturing cell-cultured collagen into its product lineup. A section of Aleph Farms' research facility, Aleph Frontiers focuses on creating novel products and technology with an eye toward ultimate commercialization.

Bovine-Based Collagen for Biomedical Applications Market Segmentation

By Applications

  • Bone Graft Substitutes
  • Collagen-based Scaffolds
  • Hemostats
  • Skin Substitutes
  • Cartilage Repairs
  • Other Applications

By Regions

  • North America
  • Europe
  • Asia-Pacific
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