Gene Synthesis Market Size & Outlook, 2025-2033

gene Synthesis Market Size

The global gene synthesis market size was valued at USD 2.20 billion in 2024 and is projected to reach from USD 2.55 billion in 2025 to USD 8.24 billion by 2033, growing at a CAGR of 15.8% during the forecast period (2025-2033).

Gene synthesis is a synthetic biology technique that produces artificial genes in a lab. It differs from molecular cloning and the polymerase chain reaction because the method relies on solid-phase DNA synthesis (PCR). Gene synthesis is utilized for molecular cloning, producing fusion proteins, or reaching high enough protein expression levels. Compared to conventional molecular cloning methods, the gene synthesis service offers unmatched top-to-bottom customizability while saving time and money.

The chemical in vitro synthesis of double-stranded DNA molecules is known as gene synthesis. It is a tool used in biotechnology and significantly impacts synthetic biology. Gene therapy, vaccine development, molecular engineering, and heterologous gene expression are just a few of the applications of recombinant DNA technology that have emerged as critical tools. It can assist in creating new enzymes for the treatment of cancer and diagnose viral genomes in real-time to develop vaccines. Gene synthesis without a template DNA strand can result in mutated, recombinant, or entirely new DNA sequences. It can also generate DNA sequences, oligos, and RNA with modified bases and chimeric DNA-RNA backbones.

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gene Synthesis Market Drivers

Escalated Adoption of Gene Therapy Technique in Molecular Biology

The creation and application of numerous cutting-edge gene-editing techniques for editing represent a significant advancement in molecular biology and gene therapy. As a result, there has been a notable advancement in the development of gene therapy for use in molecular biology. The advancement of genome engineering, the availability of user-friendly gene therapy systems, and gene therapy's ability to enable rapid genome-wide interrogation of gene function is expected to accelerate the adoption of gene therapy and genome editing technologies in molecular biology. As a result, the gene synthesis market is expected to grow during the forecast period.

Latest Developments in the Gene Synthesis

Demand in the gene synthesis market is expected to be driven by a greater emphasis on clinical research to uncover biological systems at the fundamental molecular level. Life science research is expanding due to recent technological advancements that have resulted in well-designed goods and services such as molecular separation, gene synthesis on microchips, and protein purification. Gene synthesis has been recognized as an effective and affordable substitute for conventional cloning and mutagenesis procedures. Federal funding for various academic research projects in developed countries is pushed by these dependable and efficient solutions and drives the market.

gene Synthesis Market Challenges

Lack of Skilled Professionals and Misuse of Data

One of the significant factors restraining the global market is the scarcity of industry professionals. Misuse of gene synthesis, which refers to using gene information for purposes other than forensic research, is another factor expected to reduce gene synthesis's market value. However, factors such as fierce competition, tempting price reductions, and technical limitations throughout the manufacturing process are expected to restrain the growth of the gene synthesis market shortly.

Key Market Opportunities

Growing Population with Genetic and Chronic Disorders

The global gene synthesis market is rapidly expanding due to the growing demand for gene synthesis among populations suffering from genetic and chronic disorders worldwide. Additionally, a study published in 2018 by Science Direct found that chronic diseases are one of the most significant issues in developed nations and account for 80% of deaths in middle and low-income countries due to the aging population and chronic diseases like cancer. One of the factors that will positively impact the gene synthesis market is the rising public demand for targeted and personalized medicine. In addition, increasing government, private, and public investment in synthetic biology is anticipated to speed up the global market and create lucrative business opportunities for key players in the coming years.

Regional Insights

The global gene synthesis market is segmented into North America, Europe, Asia-Pacific, and LAMEA.

North America Dominates the Global Market

North America is the largest global gene synthesis market shareholder due to significant players and government initiatives in training and implementing synthetic biology programs. The increasing use of gene editing and synthesis-related techniques by drug and diagnostic developers in the United States fosters regional market expansion. Additionally, regulatory approval and commercialization of synthetic gene products in the region have contributed to the expansion of the market. Asia-Pacific is projected to have the highest CAGR during the forecast period due to the increasing investments of multinational corporations in the regional market. In addition, the presence of key companies in emerging nations such as China and India contributes to the expansion of the market.

Method Analysis

The market is divided into solid-phase, chip-based, and PCR-based enzyme synthesis. The solid-phase segment accounts for the largest revenue share due to the highest adoption rate over the past few years. The high accuracy of this Method also encourages its use in research settings and among therapy developers. However, in some situations, its high expense and poor output make it less valuable, opening doors for alternative techniques. PCR and chip-based methods are anticipated to grow with the highest CAGR during the forecast period. These processes enable the synthesis of larger fragments at a slower rate, increasing the demand for these products.

Service Analysis

The market is categorized into antibody DNA synthesis, viral DNA synthesis, and others. The antibody DNA synthesis segment is the most dominant due to the large number of market participants providing services for antibody DNA synthesis. Businesses are supplying their services to pharmaceutical/biotech companies, academic research centers, and other organizations to enable the cloning and synthesis of antibody heavy/light chain sequences into any custom vector. The viral gene synthesis segment is anticipated to grow at the fastest CAGR due to increased virus vector-related R&D activities.

Application Analysis

The market is bifurcated into gene and cell therapy development, vaccine development, disease diagnosis, and others. The development of gene and cell therapies accounted for the largest revenue share. The pipeline of cutting-edge therapies for treating chronic conditions is expected to grow due to their superior effectiveness in treating conditions that cannot be treated using the traditional disease treatment model. These therapies are rapidly growing in popularity among therapy developers. Businesses and academic institutions worldwide are developing new therapies, likely increasing the demand for services in this market.

End-User Analysis

The market is segmented into biotechnology and pharmaceutical companies, academic and government research institutes, and contract research organizations.

The academic and governmental research institutes segment is anticipated to dominate the market due to the widespread use of gene synthesis services in research settings. Research institutes collaborate with service providers to expedite gene fragment synthesis and characterization projects.

List of key players in Gene Synthesis Market

1. GenScript
2. Brooks Automation, Inc. (GENEWIZ)
3. Boster Biological Technology
4. Twist Bioscience
5. ProteoGenix
6. Biomatik
7. ProMab Biotechnologies, Inc.
8. Thermo Fisher Scientific, Inc.
9. Integrated DNA Technologies, Inc.
10. OriGene Technologies, Inc. 

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Recent Developments

• June 2022- Twist Bioscience Corporation (NASDAQ: TWST), a company enabling customers to succeed through its offering of high-quality synthetic DNA using its silicon platform, and Ildong Pharmaceutical announced an agreement under which Ildong will license a suite of Twist VHH antibody libraries to use to discover and develop antibodies for applications in immuno-oncology.
• July 2022- Twist Bioscience Opened New Twist Boston Location to Expand Antibody Discovery Capacity. Twist Bioscience Corporation (NASDAQ: TWST), a company enabling customers to succeed through its offering of high-quality synthetic DNA using its silicon platform, announced the opening of its new Twist Boston location in Quincy, Massachusetts.