Nucleotides Market 

Market Overview

The global Nucleotides Market size accounted for USD 608 million in 2021. It is expected to reach a value of USD 1,095 million by 2030, growing at a CAGR of 7.63% during the forecast period (2022–2030).

Low-molecular-weight intracellular substances known as nucleotides are crucial for various biochemical procedures. They play a vital role in the mucosa's rapidly proliferating lymphoid and epithelial cells, which synthesize nucleic acids. The purine or pyrimidine base that makes up nucleotides may be produced inside cells from the precursors glutamine, aspartic acid, glycine, formate, and carbon dioxide. Most nucleotides in the diet come from bovine milk, which also helps with immunological function, digestion, and absorption of other micronutrients. Since it is known that human milk contains a significant amount of nucleotides, efforts have been made to include nucleotides in human infant formula. 

The use of premixes in baby feeding applications has recently gained public awareness on a global scale. The market for nucleotides is predicted to develop as a result of customers choosing newborn feeding products that contain premixes. Additionally, the global consumer base's disposable income is growing, causing them to spend more money on food items with better health advantages. As a result, consumers worldwide began choosing food products that included components like nucleotides that were good for their health.

Market Dynamics

Global Nucleotides Market Driver

Demand for Nucleotides from the Pharmaceutical Industry

The pharmaceutical industry has recently experienced tremendous growth due to increased expenditures on new pharma plant construction or expansion and new drug discoveries. The fast growth and proliferation of cells found in the immune system and digestive tract are significantly influenced by nucleotide supplementation. Exogenous nucleotides have also demonstrated potential as nutritional supplements to enhance the immune system and disease resistance. As a result, the pharmaceutical industry's need for nucleotides has been rising concurrently. 

Global Nucleotides Market Restraint

Lack of Invasion into the Aqua Feed Industry

In contrast to mammalian and human diets, nucleotides are used relatively infrequently in aquaculture. A significant barrier to nucleotide consumption in aquafeed has been a lack of knowledge about their advantages. Furthermore, overusing nucleotides is likely to have harmful effects. Food safety issues have arisen since there is a shortage of knowledge on how many nucleotides should be placed in the feed. Therefore, significant restraint on the market under study is the low level of nucleotide penetration in the aquafeed business.

Regional Analysis

Asia-Pacific Surpasses the Rest of the World

Region-wise, the global nucleotides market is segmented into North America, Europe, Asia-Pacific, South America, and the Middle East and Africa.

Asia-Pacific dominates the market and is estimated to grow at a CAGR of 8.06% during the forecast period. It is anticipated that demand for the product would rise due to the region's top nucleotide producer, growing interest in nutraceuticals, and the growth of the health food market. During the forecast period, increased research into food and beverage additives, notably in the Asia-Pacific, is projected to drive market expansion for nucleotides. China is the largest economy in the Asia-Pacific region in terms of GDP. The second-largest pharmaceutical market worldwide is found in China. Due to the country's elderly and middle-class population growth, rising affluence, and accelerating urbanization, the pharmaceutical business is expanding quickly. 

On the other hand, India's growing pharmaceutical sector is dramatically driving up nucleotide demand. Due to factors like the rising elderly population, changes in drug regulations, increasing need for chemical intermediates, medical initiatives, increased investment inflows, etc., the pharmaceutical business is growing in demand. During the projected period, the market for nucleotides in pharmaceutical production is anticipated to be driven by the rising demand for medicines from an aging population and the emergence of new ailments.

North America holds the second-largest position in the market and is anticipated to account for USD 345 million by 2030, growing at a CAGR of 7.76%. The presence of the US, which has the most outstanding economy in the world, is a crucial factor in this region's progress. One of the largest and most R&D-intensive businesses in the United States has historically been the pharmaceutical sector. The American healthcare industry is unquestionably one of the most developed in the world. The country's growing senior population and the rising need for medical facilities to treat chronic diseases have supported the expansion of the healthcare industry and pharmaceutical use there.

Europe is renowned for being the ideal setting for manufacturing, developing, and selling top-notch medicines. The nation gains from its long history of manufacturing, leading-edge research, and quick access to the global pharmaceutical market. Europe's largest pharmaceutical market is located in Germany. It is also referred to as the World's Pharmacy on the international stage. This area has increased its share of the pharmaceutical industry due to the active presence of several international pharmaceutical businesses. Continuous research is conducted to create new medications because there are many pharmaceutical businesses.

Segmental Analysis

The global nucleotides market is segmented by the nitrogenous base, application, and region.

On the Basis of Nitrogenous Base

By nitrogenous base, the global nucleotides market is bifurcated into Pyrimidine and Purine.

The Pyrimidine segment is the largest shareholder in the market. Uranium, thymine, and cytosine are all pyrimidines, which are heterocyclic amines having two nitrogen atoms arranged in a six-member ring. The heterocyclic nitrogenous base pyrimidine belongs to one of the two classes present in DNA and RNA, the nucleic acids. A diazine with two nitrogen atoms in the 1- and 3-positions, pyrimidine is the parent chemical of the pyrimidines. It functions as a metabolite of Daphnia Magna. As a prodrug, human metabolite, allergen, mouse metabolite, Daphnia Magna metabolite, Saccharomyces cerevisiae metabolite, Escherichia coli metabolite, and other metabolites, uracil serves a variety of functions.

Purines are heterocyclic amines made up of a five-member ring with two nitrogen atoms and a pyrimidine ring fused to it. The two main purines present in nucleic acids are adenine and guanine. A purine is an aromatic heterocyclic nitrogen molecule with the basic chemical formula C5H4N4. It comprises a pyrimidine ring system joined to an imidazole ring system. Purines are substances with low basicity. Most of the bonds in purines have the characteristics of partial double bonds because they are sustained by resonance among the atoms in the ring structure.

On the Basis of Application

By application, the global nucleotides market is categorized into Pharmaceuticals, Food & Animal Feed Additives, and Drug Discovery.

The Food & Animal Feed Additives segment dominates the market and is estimated to grow at a CAGR of 7.63% during the forecast period. For nutritional and physiological purposes, nucleotides are essential. The palatability of food is increased by the usage of inosine monophosphate (IMP) and guanosine monophosphate (GMP). Nucleotides' palatability for feed is improved because of this. Nucleotides also influence the intestinal epithelial cells' ability to recuperate, which enhances immunity. Self-synthesizing nucleotides are not possible in immune system tissue cells. Nucleotides found in food, therefore, boost immunity. Long strands of genetic material, which can comprise millions of nucleotides, are generally present as the nucleotides in food. Nucleotides also have the reputation of enhancing and improving taste. Nucleotides boost the complexity, intensity, continuity, and harmony of food tastes while amplifying smells' performance and enabling cost savings in formulations. These effects are achieved by enhancing the umami flavor, which increases sensory acceptability.

Animals also digest the nucleotides they ingest in their guts, which impacts the growth of good gut flora. As soon as an animal dies from respiratory arrest, the process of breaking down ATP begins, producing the catabolite nucleotides inosine monophosphate (IMP), inosine (Ino), and, eventually, hypoxanthine (Hx). A reliable predictor of the freshness of fish and meat, including beef, hog, lamb, poultry, and subproducts, is the measurement of nucleotide levels in tissues. The increased prevalence of animal illnesses drives the need to keep livestock's metabolism rates at suitable levels. Consumer awareness has also developed, raising the demand for animal feed.

The first step in the Drug Discovery process is identifying an illness with well-defined symptoms that lower the quality of life. Traditionally, a desired medicine is a substance or mixture of substances that lessen symptoms without having a significant negative impact on the patient. Drug development for illnesses including cancer and other infectious disorders uses substrate analogs of nucleotide metabolizing enzymes. Drug development is starting to pay off in several therapeutic areas, including cancer, immunology, and infectious diseases. SELEX/aptamer modification, mRNA modification, antiviral nucleotides, and cytostatic nucleotides are a few of the critical uses of nucleotides in drug discovery.

Recent Developments

• June 2022- Solutions for speeding up next-generation vaccine and therapy research and unlocking deeper analytical insights were presented by Thermo Fisher Scientific.
• March 2022- Ajinomoto Co., Inc. invested in SuperMeat, a cultivated meat startup to use cellular agriculture technology to create a sustainable food system.