Home Biotechnology Organ-On-Chip Market Size, Global Trends, Top Share, Forecast by 2033

Organ-On-Chip Market Size, Share & Trends Analysis Report By Offerings (Products, Software, Services), By Organ Type (Liver, Intestine, Kidney, Lung, Heart, Others), By Applications (Toxicology Research, Drug Discovery, Physiological Model Development, Stem Cell Research, Tissue Regeneration and Regenerative Medicines), By End-User (Pharmaceutical and Biotechnology Companies, Cosmetics Industry, Academic and Research Institutes, Others) and By Region(North America, Europe, APAC, Middle East and Africa, LATAM) Forecasts, 2025-2033

Report Code: SRBI54091DR
Last Updated : Oct 21, 2024
Author : Straits Research
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Organ-On-Chip Market Size

The global organ-on-chip market size was valued at USD 157.33 million in 2024 and is projected to reach from USD 212.36 million in 2025 to USD 2,343.50 million by 2033, exhibiting a CAGR of 32.03% during the forecast period (2025-2033).

Organs-on-chips represent a groundbreaking advancement in biomedical research, allowing scientists to create miniaturized models of human organs to study the safety and efficacy of food and medical drugs. The development of these models demands expertise across multiple disciplines, including microfabrication, microfluidics, and tissue engineering.

The COVID-19 pandemic has significantly influenced the organs-on-chips market, as researchers have leveraged this technology to gain insights into the pathophysiology of the liver in infected patients.

A notable example is the work conducted by the Center for iPS Cell Research and Application at Kyoto University, highlighted in a March 2023 article. Researchers successfully created liver-on-chip models that mimic the complex architecture of the liver, including the regions surrounding blood vessels and bile ducts. They utilized microfluidic devices to culture human hepatocytes and cholangiocytes in distinct channels, developing innovative models with intrahepatic bile ducts (ibd-LoC) and blood vessels (bv-LoC).

After two days of culture, these models were infected with SARS-CoV-2, confirming the presence of the virus in both liver structures. This pioneering application of organ-on-chip technology not only enhances our understanding of disease mechanisms but also emphasizes its potential in developing targeted therapies. As the relevance of these models continues to grow, they are poised to transform the landscape of drug development and disease research.

Organ-On-Chip Market Trends

Rising demand for rapid medical countermeasures

One prominent trend in the global market is the collaboration between research institutions and government agencies aimed at developing rapid medical countermeasures against health security threats. This collaboration has gained momentum due to the increasing need for swift and effective responses to emergencies, such as radiological and nuclear incidents.

  • For example, in 2023, the FDA awarded a partial option to Harvard University's Wyss Institute for Biologically Inspired Engineering to develop organ chips specifically designed to advance radiation countermeasure research.

This initiative highlights the growing recognition of organ-on-chip technologies as critical tools for understanding the physiological impacts of radiation exposure and developing effective treatment protocols.

Growing focus on personalized medicine

The emphasis on personalized medicine is increasingly shaping the OoC market as healthcare moves towards more individualized treatment strategies. OoC technologies offer relevant human models that can accurately mimic individual patient responses to drugs, enabling researchers and clinicians to tailor therapies to specific needs.

  • For instance, in August 2023, researchers at the Wyss Institute developed an organ-on-chip model with immune-infiltrated human kidney organoids, enabling the study of immune responses in kidney function. This approach led to personalized treatments for kidney diseases.

By leveraging OoC technologies, researchers can better understand how different patients might respond to various therapies, ultimately enhancing the effectiveness of treatment approaches.

Organ-On-Chip Market

Organ-On-Chip Market Growth Factors

Increasing government initiatives to reduce animal testing

A major growth factor for the OoC market is the increasing number of government initiatives aimed at reducing reliance on animal testing. Regulatory bodies like the FDA and EMA are advocating for the use of alternative testing methods, which has led to a more favorable environment for OoC technologies.

These initiatives include funding and grants designed to support research institutions and companies dedicated to developing organ-on-chip solutions. Additionally, public awareness campaigns emphasizing ethical concerns related to animal welfare are pressuring policymakers to promote more humane research practices.

  • For example, in September 2023, the U.S. FDA enacted the Modernization Act 2.0, which aims to significantly cut down animal drug testing by encouraging the adoption of alternative methods such as organ-on-chips.

This legislative action serves as a critical driver of growth in the market, as it not only supports innovation but also aligns with evolving ethical standards in research.

Increased investment in chronic disease research

The growing prevalence of chronic diseases is another significant driver for the global market, underscoring the urgent need for rapid drug development and toxicity assessments. With conditions like diabetes, cancer, and cardiovascular diseases becoming more common, the demand for effective treatments is increasing. OoC technologies enhance personalized medicine by providing relevant human models for drug testing and facilitating faster development processes, particularly in evaluating the long-term toxicity of treatments.

Moreover, increased investment in research further emphasizes the demand for innovative drug strategies, positioning organ-on-chip technologies as essential tools in modern biomedical research.

  • For instance, the Dutch Research Council (NWO) allocated USD 25.36 million to seven innovative scientific infrastructure projects, including over USD 3.35 million for the Organ-on-Chip Development Center (hDMT INFRA OoCDev) at the University of Twente.

This center aims to expedite the adoption of organ-on-chip technology, highlighting the critical role of investment in driving advancements in the field.

Restraining Factors

Constrained throughput and scalability in OoC technologies

One of the primary restraints for the organ-on-chip (OoC) market is the limited throughput and scalability of these technologies compared to traditional 2D cell cultures. While OoC technologies offer advanced physiological modeling and insights, they often struggle to handle large sample sizes effectively. This limitation can lead to extended development timelines and reduced efficiency in experimental processes.

Researchers and pharmaceutical companies may find themselves hesitant to fully embrace OoC systems, favoring the more established 2D cultures that readily accommodate higher throughput demands. This preference stems from the necessity for rapid results and large-scale testing in drug development and research, where time and efficiency are critical.

Consequently, the challenges related to throughput and scalability serve as significant barriers to the broader adoption of OoC technologies, potentially hindering innovation and progress in the field.

Market Opportunities

Integration with AI and Machine Learning

The integration of artificial intelligence (AI) and machine learning (ML) with organ-on-chip (OoC) technologies presents a transformative opportunity for the market. AI and ML can significantly enhance data analysis, predictive modeling, and automation capabilities in OoC systems, making them more efficient and precise.

  • For example, AI algorithms can analyze the vast amount of data generated by OoC platforms, identifying patterns in cellular behavior and disease progression more quickly than manual methods. This accelerates drug discovery processes by predicting drug efficacy and potential side effects.

A notable case is the collaboration between Emulate, an OoC company, and pharmaceutical firms, where AI-driven models are used to predict human organ responses to drugs. By combining AI with OoC systems, researchers can simulate complex biological processes and predict outcomes with greater accuracy. This integration can also reduce the cost and time of preclinical trials, offering significant advancements in personalized medicine and toxicology testing.

This approach accelerates breakthroughs and enhances the overall reliability of OoC platforms.

Study Period 2021-2033 CAGR 32.03%
Historical Period 2021-2023 Forecast Period 2025-2033
Base Year 2024 Base Year Market Size USD 157.33 million
Forecast Year 2033 Forecast Year Market Size USD 2,343.50 million
Largest Market North America Fastest Growing Market
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Regional Insights

North America: Dominant region with 50.23% market share

North America holds a leading position in the global market. Various initiatives to offer organ-on-chip services, along with recent approvals and product launches in North America, are driving market growth.

  • For instance, in May 2022, Nikon Instruments Inc. announced its plan to launch contract services for organ-on-a-chip imaging and analysis aimed at optimizing research and development for drug discovery.

Moreover, various supportive government initiatives in North America are driving market growth, such as the FDA's collaboration with the National Institute of Allergy and Infectious Diseases (NIAID) to advance the development of organ-on-a-chip models to assess medical countermeasures for COVID-19. All the aforementioned factors are propelling the market growth.

Europe: Fastest growing region with the highest market CAGR

Europe is projected to experience the fastest organ-on-chip (OoC) market growth, driven by substantial investments in biomedical research and innovation across key countries like Germany, the UK, Italy, France, and Spain. These nations are at the forefront of advancing OoC technologies, with Germany and the UK, in particular, having strong research ecosystems that foster the development of innovative healthcare solutions. Moreover, initiatives such as Horizon Europe provide extensive funding and support for cutting-edge research, accelerating both the creation and commercialization of OoC systems.

Country Insights

The global organ-on-chip market is a rapidly growing sector within biotech R&D focused on creating micro-engineered systems to mimic human organ functions. These devices allow researchers to study diseases, test drug efficacy, and evaluate toxicity more accurately and ethically than traditional animal testing.

Below is the analysis of key countries impacting the market:

  • U.S.- The U.S. leads the organ-on-chip (OoC) market due to its growing demand for innovative drug development technologies. In 2024, the American Cancer Society projects that approximately 234,580 people will be diagnosed with lung cancer in the U.S., highlighting the critical need for advancements in drug testing. OoC systems, particularly lung-on-chip models, offer more accurate simulations of lung function, providing a powerful alternative to traditional drug testing methods and accelerating breakthroughs in treatments for lung cancer and other respiratory diseases.
  • Canada- Heart disease remains a significant health concern in Canada, as it is the second leading cause of death, claiming over 50,000 lives annually, according to the Government of Canada. This high mortality rate is driving demand for cardiac health innovations, including heart-on-chip technologies. These systems offer researchers the ability to simulate human heart function in a controlled environment, enabling more precise drug testing and reducing reliance on animal models, which supports the growth of the OoC market in Canada.
  • India- India is seeing a rising demand to replace animal testing in drug development and research, which is a key driver of OoC market growth. In August 2024, the Government of India introduced the 'BioE3' policy to establish biomanufacturing facilities, bio-AI hubs, and bio-foundries to promote biotechnological advancements. This policy aligns with global trends toward ethical, efficient alternatives to animal testing and is expected to accelerate the development and adoption of OoC technologies across the country.
  • China: As of November 2023, the World Health Organization (WHO) reported that nearly 100 million people in China are living with chronic obstructive pulmonary disease (COPD), representing about 25% of all COPD cases worldwide. This alarming prevalence of COPD is driving demand for OoC technology, particularly lung-on-chip systems, to enable more effective disease management and drug testing. China’s growing healthcare focus on chronic diseases is expected to fuel market growth in the coming years.
  • Japan: Japan is making significant strides in the regional market, driven by technological advancements from key players. For example, in May 2022, Nikon Corporation launched light-driven on-chip actuators designed to mimic biological organ movements, contributing to the development of bio-digital twins. These twins simulate organ functions for applications in drug discovery, regenerative medicine, and artificial organ development, pushing the frontier of medical research in Japan and reducing reliance on animal testing models.
  • Germany: Biotechnology companies in Germany are actively investing in the development of new OoC models. In March 2024, Dynamic42, a biotech firm based in Jena, launched a new intestine-on-chip model to advance research on candidiasis, a serious fungal infection. This technology enables detailed analysis of pathogen-host interactions, improving drug testing precision and reducing the need for animal models, thus bolstering the country’s position in the market.
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Organ-On-Chip Market Segmentation Analysis

By Offerings

The market is bifurcated into products, software, and services. The products segment, especially the instruments and consumables, continues to dominate the OoC market, holding the largest market revenue share. Instruments such as microfluidic devices, pumps, and sensors are crucial for recreating the dynamic environments of human organs, making them indispensable in research and pharmaceutical testing. The consumables, including reagents and cell culture media, see consistent demand due to their one-time-use nature, further boosting revenue.

Additionally, the integration of advanced technologies, such as automated systems and AI-driven analytics, enhances the performance and precision of these instruments, driving increased adoption in research laboratories, biotechnology companies, and academic institutions. This growing reliance on cutting-edge instruments not only accelerates scientific breakthroughs but also cements the leadership of this segment within the market.

By Organ Type

The market is bifurcated into liver, intestine, kidney, lung, heart, and others. The lung segment dominates the global market, holding the largest revenue driven by advancements in modeling airborne nanoparticle absorption and replicating inflammatory responses to microbial pathogens. The increasing prevalence of pulmonary diseases, particularly tuberculosis (TB), heightened the demand for effective management solutions. According to the CDC, approximately two billion people, or one-fourth of the global population, are infected with TB each year.

In response, key players are innovating new solutions.

  • For instance, in June 2022, the Charles Stark Draper Laboratory launched a lung-on-chip model that analyzed around 3,000 data points to identify antiviral compounds that inhibit viral replication in lung tissues, underscoring the technology's vital role in tackling significant health challenges.

By Application

The market is bifurcated into toxicology research, drug discovery, physiological model development, stem cell research, and tissue regeneration and regenerative medicines. The drug discovery segment dominates the global market, holding the largest market revenue as OoC technologies significantly streamline the drug development process. These systems allow for more accurate modeling of human responses, reducing the reliance on animal testing and improving the predictive power of preclinical studies. The global push towards more efficient drug discovery processes is boosting investments in this area.

  • For instance, in March 2022, Charles Stark Draper Laboratory, Inc., a provider of organ-on-a-chip and bioprocessing systems, announced a strategic plan to enhance its organ-on-a-chip technology in response to the growing focus on targeted and advanced therapeutics in drug development.

By End-User

The market is divided into pharmaceutical and biotechnology companies, cosmetics industry, academic and research institutes, and others. Pharmaceutical and biotechnology companies dominate the global market due to their extensive research needs and funding capabilities. These organizations are heavily invested in developing new drugs and therapies, making them key adopters of these technologies.

  • For instance, in July 2023, Hesperos, Inc., a biotechnology company, announced the development of a groundbreaking Malaria-on-a-Chip disease model aimed at enhancing drug efficacy evaluation and off-target toxicity assessments.

Market Size By Offerings

Market Size By Offerings
  • Products
  • Software
  • Services


  • Company Market Share

    The organ-on-chip market is characterized by several key players implementing strategic initiatives to strengthen their market positions, providing valuable market insights into the industry's competitive dynamics. Likewise, key players are engaging in product launches to enhance their offerings and market presence.

    These innovations highlight the dynamic nature of the market and the commitment of leading companies to advance organ-on-chip technology for various applications.

    Valo Health: An emerging player in the global organ-on-chip market

    Valo Health is gaining attention in the organ-on-a-chip market due to its innovative approach that combines artificial intelligence (AI) with organ-on-a-chip technology. This unique integration allows for more predictive modeling of human biology and disease, which can accelerate drug discovery and development processes.

    Recent developments at Valo Health include:

    • In April 2022, Valo Health acquired TARA Biosystems, renowned for its "heart-on-a-chip" technology that simulates cardiac function to predict drug responses. This integration with Valo's Opal data platform aims to enhance drug development for cardiovascular diseases by identifying targets and conducting preclinical testing.

    List of key players in Organ-On-Chip Market

    1. Emulate, Inc.
    2. MIMETAS B.V.
    3. Valo Health
    4. Nortis, Inc.
    5. AxoSim
    6. BICO - THE BIO CONVERGENCE COMPANY
    7. CN Bio Innovations Ltd
    8. SynVivo, Inc.
    9. The Charles Stark Draper Laboratory, Inc
    10. AlveoliX AG
    11. TissUse GmBH
    12. BEOnchip
    13. Netri
    14. Insphero
    15. Obatala Sciences
    Organ-On-Chip Market Share of Key Players

    Recent Developments

    • September 2024 - The Government of India announced the ‘BioE3’ policy to drive innovation in biotechnology, with organ-on-chip (OoC) technology playing a pivotal role. The policy focuses on establishing biomanufacturing facilities, bio-AI hubs, and bio-foundries to promote advancements like precision therapeutics, which personalize treatments based on patient needs.

    Analyst Opinion

    According to our analyst, the global organ-on-chip (OoC) industry is rapidly emerging as a disruptive technology in the healthcare and biotechnology sectors. The market offers substantial opportunities, particularly in drug discovery, personalized medicine, and reducing dependence on animal testing.

    Moreover, OoC platforms replicate human organ functions in vitro, offering a more precise and efficient approach to preclinical testing. This helps pharmaceutical companies reduce clinical trial failure rates and significantly lower R&D costs.

    As a result, major pharmaceutical and biotech firms are actively investing in the development and integration of OoC technology to streamline drug development and improve the predictive accuracy of human responses.


    Organ-On-Chip Market Segmentations

    By Offerings (2021-2033)

    • Products
      • Instruments
      • Consumables & Accessories
    • Software
    • Services
      • Custom Services
      • Standard Services

    By Organ Type (2021-2033)

    • Liver
    • Intestine
    • Kidney
    • Lung
    • Heart
    • Others

    By Applications (2021-2033)

    • Toxicology Research
    • Drug Discovery
    • Physiological Model Development
    • Stem Cell Research
    • Tissue Regeneration and Regenerative Medicines

    By End-User (2021-2033)

    • Pharmaceutical and Biotechnology Companies
    • Cosmetics Industry
    • Academic and Research Institutes
    • Others

    Frequently Asked Questions (FAQs)

    How much is the organ-on-chip market worth?
    Straits research predicts that the global organ-on-chip market size was valued at USD 157.33 million in 2024 and is projected to reach from USD 212.36 million in 2025 to USD 2,343.50 million by 2033.
    The global market growth rate growing at a 32.03% from 2025 to 2033.
    The increasing government initiatives to reduce animal testing, is a key growth factor driving advancements in organ-on-chip.
    North America holds the largest market share with various supportive government initiatives in North America.
    Currently, the lung segment dominates the market, fueled by advancements in modeling airborne nanoparticle absorption and replicating inflammatory responses to microbial pathogens.


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